Studies of variability in the PTEN gene among Danish caucasian patients with Type II diabetes mellitus

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Abstract

Phosphatase and tensin homologue deleted from chromosome ten (PTEN) has recently been characterized as a novel member in the expanding network of proteins regulating the intracellular effects of insulin. By dephosphorylation of phosphatidyl-inositol-(3, 4, 5)-trisphosphate (PIP3) the PTEN protein regulates the insulin-dependent phosphoinositide 3-kinase (PI3K) signalling cassette and accordingly might function as a regulator of insulin sensitivity in skeletal muscle and adipose tissue. In this study we tested PTEN as a candidate gene for insulin resistance and late-onset Type II (non-insulin-dependent) diabetes mellitus in a Danish Caucasian population.
Original languageEnglish
JournalDiabetologia
Volume44
Issue number2
Pages (from-to)237-240
Number of pages4
ISSN0012-186X
DOIs
Publication statusPublished - Feb 2001

Keywords

  • Adipose Tissue
  • Adult
  • Aged
  • Blood Glucose
  • Blood Pressure
  • C-Peptide
  • Denmark
  • Diabetes Mellitus, Type 2
  • European Continental Ancestry Group
  • Exons
  • Fasting
  • Gene Frequency
  • Humans
  • Insulin
  • Insulin Resistance
  • Middle Aged
  • Muscle, Skeletal
  • PTEN Phosphohydrolase
  • Phosphatidylinositol 3-Kinases
  • Phosphatidylinositol Phosphates
  • Phosphoric Monoester Hydrolases
  • Polymerase Chain Reaction
  • Polymorphism, Genetic
  • Polymorphism, Restriction Fragment Length
  • Polymorphism, Single-Stranded Conformational
  • Tumor Suppressor Proteins

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