18F-FDG PET/CT findings in cytomegalovirus colitis

Anna Sophie L. Kjaer; Iben Ribberholt; Kim Thomsen; Per H. Ibsen; Elena Markova; Jesper Graff

doi:10.3390/diagnostics9010003

¹⁸F-FDG PET/CT findings in cytomegalovirus colitis

Anna Sophie L. Kjaer^*, Iben Ribberholt, Kim Thomsen, Per H. Ibsen, Elena Markova, Jesper Graff

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › Research › peer-review

4 Citations (Scopus)

64 Downloads (Pure)

Abstract

We present a case demonstrating the diagnostic work-up of a patient undergoing azathioprine treatment for inflammatory bowel disease (IBD), diagnosed with an acute cytomegalovirus (CMV) infection and CMV colitis. An ¹⁸F-FDG positron emission tomography/computed tomography (PET/CT) performed 2 weeks after debut of symptoms revealed pathological ¹⁸F-FDG uptake in the left side of the colon mucosa, mimicked activity of IBD. However, a diagnosis of CMV colitis was based on the presence of CMV IgM antibodies, a seroconversion of CMV IgG antibodies, presence of CMV DNA in plasma and the finding af CMV DNA in biopsies from the intestinal mucosa. The patient responded to treatment with ganciclovir. This case highlights that a positive ¹⁸F-FDG PET/CT scan of the colon can be due to CMV colitis.

Original language	English
Article number	3
Journal	Diagnostics
Volume	9
Issue number	1
ISSN	2075-4418
DOIs	https://doi.org/10.3390/diagnostics9010003
Publication status	Published - 2019

Keywords

F-FDG PET/CT
Cytomegalovirus colitis
Inflammatory bowel disease

Access to Document

10.3390/diagnostics9010003Licence: CC BY

18F-FDG PET/CT Findings in Cytomegalovirus ColitisFinal published version, 315 KBLicence: CC BY

Cite this

@article{17720ab722a54247a3f41f84d3752248,

title = "18F-FDG PET/CT findings in cytomegalovirus colitis",

abstract = "We present a case demonstrating the diagnostic work-up of a patient undergoing azathioprine treatment for inflammatory bowel disease (IBD), diagnosed with an acute cytomegalovirus (CMV) infection and CMV colitis. An 18F-FDG positron emission tomography/computed tomography (PET/CT) performed 2 weeks after debut of symptoms revealed pathological 18F-FDG uptake in the left side of the colon mucosa, mimicked activity of IBD. However, a diagnosis of CMV colitis was based on the presence of CMV IgM antibodies, a seroconversion of CMV IgG antibodies, presence of CMV DNA in plasma and the finding af CMV DNA in biopsies from the intestinal mucosa. The patient responded to treatment with ganciclovir. This case highlights that a positive 18F-FDG PET/CT scan of the colon can be due to CMV colitis.",

keywords = "F-FDG PET/CT, Cytomegalovirus colitis, Inflammatory bowel disease",

author = "Kjaer, {Anna Sophie L.} and Iben Ribberholt and Kim Thomsen and Ibsen, {Per H.} and Elena Markova and Jesper Graff",

year = "2019",

doi = "10.3390/diagnostics9010003",

language = "English",

volume = "9",

journal = "Diagnostics",

issn = "2075-4418",

publisher = "MDPI AG",

number = "1",

}

TY - JOUR

T1 - 18F-FDG PET/CT findings in cytomegalovirus colitis

AU - Kjaer, Anna Sophie L.

AU - Ribberholt, Iben

AU - Thomsen, Kim

AU - Ibsen, Per H.

AU - Markova, Elena

AU - Graff, Jesper

PY - 2019

Y1 - 2019

N2 - We present a case demonstrating the diagnostic work-up of a patient undergoing azathioprine treatment for inflammatory bowel disease (IBD), diagnosed with an acute cytomegalovirus (CMV) infection and CMV colitis. An 18F-FDG positron emission tomography/computed tomography (PET/CT) performed 2 weeks after debut of symptoms revealed pathological 18F-FDG uptake in the left side of the colon mucosa, mimicked activity of IBD. However, a diagnosis of CMV colitis was based on the presence of CMV IgM antibodies, a seroconversion of CMV IgG antibodies, presence of CMV DNA in plasma and the finding af CMV DNA in biopsies from the intestinal mucosa. The patient responded to treatment with ganciclovir. This case highlights that a positive 18F-FDG PET/CT scan of the colon can be due to CMV colitis.

AB - We present a case demonstrating the diagnostic work-up of a patient undergoing azathioprine treatment for inflammatory bowel disease (IBD), diagnosed with an acute cytomegalovirus (CMV) infection and CMV colitis. An 18F-FDG positron emission tomography/computed tomography (PET/CT) performed 2 weeks after debut of symptoms revealed pathological 18F-FDG uptake in the left side of the colon mucosa, mimicked activity of IBD. However, a diagnosis of CMV colitis was based on the presence of CMV IgM antibodies, a seroconversion of CMV IgG antibodies, presence of CMV DNA in plasma and the finding af CMV DNA in biopsies from the intestinal mucosa. The patient responded to treatment with ganciclovir. This case highlights that a positive 18F-FDG PET/CT scan of the colon can be due to CMV colitis.

KW - F-FDG PET/CT

KW - Cytomegalovirus colitis

KW - Inflammatory bowel disease

U2 - 10.3390/diagnostics9010003

DO - 10.3390/diagnostics9010003

M3 - Journal article

C2 - 30587768

AN - SCOPUS:85066422532

VL - 9

JO - Diagnostics

JF - Diagnostics

SN - 2075-4418

IS - 1

M1 - 3

ER -