Svær føtal anæmi på grund af uerkendt alloimmunisering hos RhD-positiv gravid kvinde

Rikke Krabek; Thomas Bergholt; Marianne Johansen; Lone Nikoline Nørgaard; Christian Heiring; Morten Hanefeld Dziegiel; Charlotte Kvist Ekelund

Svær føtal anæmi på grund af uerkendt alloimmunisering hos RhD-positiv gravid kvinde

Translated title of the contribution: Severe foetal anaemia caused by undetected alloimmunisation in a RhD-positive pregnant woman

Rikke Krabek, Thomas Bergholt, Marianne Johansen, Lone Nikoline Nørgaard, Christian Heiring, Morten Hanefeld Dziegiel, Charlotte Kvist Ekelund

Research output: Contribution to journal › Journal article › Research

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Abstract

The incidence of haemolytic disease of the foetus or newborn (HDFN) has decreased considerably in Denmark since the introduction of routine administration of prophylactic anti-D immunoglobulin to RhD-negative pregnant women carrying a RhD-positive foetus. RhD-positive pregnant women are screened for irregular antibodies only in the first trimester of their pregnancy, as their risk of clinically relevant immunisation during pregnancy has been considered very low. This is a case report of severe undetected alloimmunisation causing fatal HDFN after the first trimester in a RhD-positive woman.

Translated title of the contribution	Severe foetal anaemia caused by undetected alloimmunisation in a RhD-positive pregnant woman
Original language	Danish
Article number	V02210124
Journal	Ugeskrift for Laeger
Volume	183
Issue number	32
ISSN	0041-5782
Publication status	Published - 2021

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https://content.ugeskriftet.dk/sites/default/files/scientific_article_files/2021-07/v02210124_web.pdf

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Svær føtal anæmi på grund af uerkendt alloimmunisering hos RhD-positiv gravid kvinde. / Krabek, Rikke; Bergholt, Thomas ; Johansen, Marianne; Nørgaard, Lone Nikoline; Heiring, Christian; Dziegiel, Morten Hanefeld ; Ekelund, Charlotte Kvist.

In: Ugeskrift for Laeger, Vol. 183, No. 32, V02210124, 2021.

Research output: Contribution to journal › Journal article › Research

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abstract = "The incidence of haemolytic disease of the foetus or newborn (HDFN) has decreased considerably in Denmark since the introduction of routine administration of prophylactic anti-D immunoglobulin to RhD-negative pregnant women carrying a RhD-positive foetus. RhD-positive pregnant women are screened for irregular antibodies only in the first trimester of their pregnancy, as their risk of clinically relevant immunisation during pregnancy has been considered very low. This is a case report of severe undetected alloimmunisation causing fatal HDFN after the first trimester in a RhD-positive woman.",

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AU - Johansen, Marianne

AU - Nørgaard, Lone Nikoline

AU - Heiring, Christian

AU - Dziegiel, Morten Hanefeld

AU - Ekelund, Charlotte Kvist

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AB - The incidence of haemolytic disease of the foetus or newborn (HDFN) has decreased considerably in Denmark since the introduction of routine administration of prophylactic anti-D immunoglobulin to RhD-negative pregnant women carrying a RhD-positive foetus. RhD-positive pregnant women are screened for irregular antibodies only in the first trimester of their pregnancy, as their risk of clinically relevant immunisation during pregnancy has been considered very low. This is a case report of severe undetected alloimmunisation causing fatal HDFN after the first trimester in a RhD-positive woman.

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