Syndecan-2 regulation of morphology in breast carcinoma cells is dependent on RhoGTPases

Hooi Ching Lim; John Robert Couchman

doi:10.1016/j.bbagen.2014.01.018

Syndecan-2 regulation of morphology in breast carcinoma cells is dependent on RhoGTPases

Hooi Ching Lim
, John Robert Couchman

Nutritional Immunology

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

While syndecan-2 is usually considered a mesenchymal transmembrane proteoglycan, it can be upregulated in some tumour cells, such as the malignant breast carcinoma cell line, MDA-MB231. Depletion of this syndecan by siRNA, but not other syndecans, has a marked effect on cell morphology, increasing spreading, microfilament bundle and focal adhesion formation, with reduced cell migration.

Original language	English
Journal	BBA General Subjects
Volume	1840
Issue number	8
Pages (from-to)	2482–2490
Number of pages	9
ISSN	0304-4165
DOIs	https://doi.org/10.1016/j.bbagen.2014.01.018
Publication status	Published - 18 Jan 2014

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Cite this

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title = "Syndecan-2 regulation of morphology in breast carcinoma cells is dependent on RhoGTPases",

abstract = "While syndecan-2 is usually considered a mesenchymal transmembrane proteoglycan, it can be upregulated in some tumour cells, such as the malignant breast carcinoma cell line, MDA-MB231. Depletion of this syndecan by siRNA, but not other syndecans, has a marked effect on cell morphology, increasing spreading, microfilament bundle and focal adhesion formation, with reduced cell migration.",

author = "Lim, \{Hooi Ching\} and Couchman, \{John Robert\}",

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AU - Lim, Hooi Ching

AU - Couchman, John Robert

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N2 - While syndecan-2 is usually considered a mesenchymal transmembrane proteoglycan, it can be upregulated in some tumour cells, such as the malignant breast carcinoma cell line, MDA-MB231. Depletion of this syndecan by siRNA, but not other syndecans, has a marked effect on cell morphology, increasing spreading, microfilament bundle and focal adhesion formation, with reduced cell migration.

AB - While syndecan-2 is usually considered a mesenchymal transmembrane proteoglycan, it can be upregulated in some tumour cells, such as the malignant breast carcinoma cell line, MDA-MB231. Depletion of this syndecan by siRNA, but not other syndecans, has a marked effect on cell morphology, increasing spreading, microfilament bundle and focal adhesion formation, with reduced cell migration.

U2 - 10.1016/j.bbagen.2014.01.018

DO - 10.1016/j.bbagen.2014.01.018

M3 - Journal article

C2 - 24447566

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VL - 1840

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JO - BBA General Subjects

JF - BBA General Subjects

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