Synthesis and antioxidant capacity of novel stable 5-tellurofuranose derivatives

Elton L. Borges; Marta T. Ignasiak; Yuliia Velichenko; Gelson Perin; Craig A. Hutton; Michael J. Davies; Carl H. Schiesser

doi:10.1039/c8cc00565f

Synthesis and antioxidant capacity of novel stable 5-tellurofuranose derivatives

Elton L. Borges, Marta T. Ignasiak, Yuliia Velichenko, Gelson Perin, Craig A. Hutton, Michael J. Davies, Carl H. Schiesser

Inflammation, Metabolism and Oxidation

Research output: Contribution to journal › Journal article › Research › peer-review

14 Citations (Scopus)

Abstract

Novel stable tellurium-containing carbohydrate derivatives are prepared from hexitols and pentitols through a double nucleophilic substitution with NaHTe in PEG-400. These tellurosugars react at very high rates with two-electron oxidants, including hypochlorous and peroxynitrous acid, formed at sites of inflammation, and show considerable promise as protective agents against oxidative damage.

Original language	English
Journal	Chemical Communications
Volume	54
Issue number	24
Pages (from-to)	2990-2993
ISSN	1359-7345
DOIs	https://doi.org/10.1039/c8cc00565f
Publication status	Published - 25 Mar 2018

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10.1039/c8cc00565f

Cite this

Synthesis and antioxidant capacity of novel stable 5-tellurofuranose derivatives. / Borges, Elton L.; Ignasiak, Marta T.; Velichenko, Yuliia; Perin, Gelson; Hutton, Craig A.; Davies, Michael J.; Schiesser, Carl H.

In: Chemical Communications, Vol. 54, No. 24, 25.03.2018, p. 2990-2993.

Research output: Contribution to journal › Journal article › Research › peer-review

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AU - Schiesser, Carl H.

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