Synthesis and characterization of dinucleoside phosphorodithioates

John Nielsen; Wolfgang K D Brill; Marvin H. Caruthers

doi:10.1016/0040-4039(88)85045-7

Synthesis and characterization of dinucleoside phosphorodithioates

John Nielsen^*, Wolfgang K D Brill, Marvin H. Caruthers

^*Corresponding author for this work

Natural Products and Peptides

Research output: Contribution to journal › Journal article › Research › peer-review

99 Citations (Scopus)

Abstract

Dinucleoside phosphoramidites, H₂S, and tetrazole react to form dinucleoside H-phosphonothioates. Oxidation with sulfur yields phosphorodithioates. Iodine oxidation in the presence of amines, alcohols, or water yields phosphorothioamidates, thiotriesters or thiodiesters.

Original language	English
Journal	Tetrahedron Letters
Volume	29
Issue number	24
Pages (from-to)	2911-2914
Number of pages	4
ISSN	0040-4039
DOIs	https://doi.org/10.1016/0040-4039(88)85045-7
Publication status	Published - 1 Jan 1988

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title = "Synthesis and characterization of dinucleoside phosphorodithioates",

abstract = "Dinucleoside phosphoramidites, H2S, and tetrazole react to form dinucleoside H-phosphonothioates. Oxidation with sulfur yields phosphorodithioates. Iodine oxidation in the presence of amines, alcohols, or water yields phosphorothioamidates, thiotriesters or thiodiesters.",

author = "John Nielsen and Brill, {Wolfgang K D} and Caruthers, {Marvin H.}",

year = "1988",

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T1 - Synthesis and characterization of dinucleoside phosphorodithioates

AU - Nielsen, John

AU - Brill, Wolfgang K D

AU - Caruthers, Marvin H.

PY - 1988/1/1

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N2 - Dinucleoside phosphoramidites, H2S, and tetrazole react to form dinucleoside H-phosphonothioates. Oxidation with sulfur yields phosphorodithioates. Iodine oxidation in the presence of amines, alcohols, or water yields phosphorothioamidates, thiotriesters or thiodiesters.

AB - Dinucleoside phosphoramidites, H2S, and tetrazole react to form dinucleoside H-phosphonothioates. Oxidation with sulfur yields phosphorodithioates. Iodine oxidation in the presence of amines, alcohols, or water yields phosphorothioamidates, thiotriesters or thiodiesters.

U2 - 10.1016/0040-4039(88)85045-7

DO - 10.1016/0040-4039(88)85045-7

M3 - Journal article

AN - SCOPUS:0023927239

SN - 0040-4039

VL - 29

SP - 2911

EP - 2914

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 24

ER -