Synthesis of new isoxazoline-based acidic amino acids and investigation of their affinity and selectivity profile at ionotropic glutamate receptors

Andrea Pinto, Paola Conti, Giovanni Grazioso, Lucia Tamborini, Ulf Madsen, Birgitte Nielsen, Carlo De Micheli

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    19 Citations (Scopus)

    Abstract

    The synthesis of four new isoxazoline-based amino acids being analogues of previously described glutamate receptor ligands is reported and their affinity for ionotropic glutamate receptors is analyzed in comparison with that of selected model compounds. Molecular modelling investigations have been carried out to rationalize the interaction with the NMDA receptors.
    Original languageEnglish
    JournalEuropean Journal of Medicinal Chemistry
    Volume46
    Issue number2
    Pages (from-to)787-793
    ISSN0223-5234
    DOIs
    Publication statusPublished - 1 Feb 2011

    Keywords

    • Former Faculty of Pharmaceutical Sciences

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