Synthetic matrix metalloproteinase inhibitors inhibit growth of established breast cancer osteolytic lesions and prolong survival in mice

Bent Winding; Róisín NicAmhlaoibh; Henriette Misander; Pernille Høegh-Andersen; Thomas Levin Andersen; Claus Holst-Hansen; Anne-Marie Heegaard; Niels Taekker Foged; Nils Brünner; Jean-Marie Delaissé

Synthetic matrix metalloproteinase inhibitors inhibit growth of established breast cancer osteolytic lesions and prolong survival in mice

Bent Winding, Róisín NicAmhlaoibh, Henriette Misander, Pernille Høegh-Andersen, Thomas Levin Andersen, Claus Holst-Hansen, Anne-Marie Heegaard, Niels Taekker Foged, Nils Brünner, Jean-Marie Delaissé

Research output: Contribution to journal › Journal article › Research › peer-review

58 Citations (Scopus)

Abstract

Breast cancer frequently leads to incurable bone metastasis. Essential requirements for the development of bone metastasis are cell-cell and cell-matrix interactions, release of bioactive growth factors and cytokines, and removal of large amounts of bone matrix. Matrix metalloproteinases (MMPs) play an important role in all of these processes, but the possibility of using synthetic MMP inhibitors to decrease bone metastasis has received little attention.

Original language	English
Journal	Clinical Cancer Research
Volume	8
Issue number	6
Pages (from-to)	1932-9
Number of pages	8
ISSN	1078-0432
Publication status	Published - 2002

Keywords

Animals
Antineoplastic Agents
Bone Neoplasms
Breast Neoplasms
Cell Survival
Dipeptides
Female
Gene Therapy
Humans
Matrix Metalloproteinases
Mice
Mice, Inbred BALB C
Mice, Nude
Neoplasm Invasiveness
Osteolysis
Phenylalanine
Protease Inhibitors
Thiophenes
Transfection
Transplantation, Heterologous
Tumor Cells, Cultured

Cite this

@article{ed8f47025e1a4aff813d9cfaba4461d4,

title = "Synthetic matrix metalloproteinase inhibitors inhibit growth of established breast cancer osteolytic lesions and prolong survival in mice",

abstract = "Breast cancer frequently leads to incurable bone metastasis. Essential requirements for the development of bone metastasis are cell-cell and cell-matrix interactions, release of bioactive growth factors and cytokines, and removal of large amounts of bone matrix. Matrix metalloproteinases (MMPs) play an important role in all of these processes, but the possibility of using synthetic MMP inhibitors to decrease bone metastasis has received little attention.",

keywords = "Animals, Antineoplastic Agents, Bone Neoplasms, Breast Neoplasms, Cell Survival, Dipeptides, Female, Gene Therapy, Humans, Matrix Metalloproteinases, Mice, Mice, Inbred BALB C, Mice, Nude, Neoplasm Invasiveness, Osteolysis, Phenylalanine, Protease Inhibitors, Thiophenes, Transfection, Transplantation, Heterologous, Tumor Cells, Cultured",

author = "Bent Winding and R{\'o}is{\'i}n NicAmhlaoibh and Henriette Misander and Pernille H{\o}egh-Andersen and Andersen, {Thomas Levin} and Claus Holst-Hansen and Anne-Marie Heegaard and Foged, {Niels Taekker} and Nils Br{\"u}nner and Jean-Marie Delaiss{\'e}",

year = "2002",

language = "English",

volume = "8",

pages = "1932--9",

journal = "Clinical Cancer Research",

issn = "1078-0432",

publisher = "American Association for Cancer Research (A A C R)",

number = "6",

}

TY - JOUR

T1 - Synthetic matrix metalloproteinase inhibitors inhibit growth of established breast cancer osteolytic lesions and prolong survival in mice

AU - Winding, Bent

AU - NicAmhlaoibh, Róisín

AU - Misander, Henriette

AU - Høegh-Andersen, Pernille

AU - Andersen, Thomas Levin

AU - Holst-Hansen, Claus

AU - Heegaard, Anne-Marie

AU - Foged, Niels Taekker

AU - Brünner, Nils

AU - Delaissé, Jean-Marie

PY - 2002

Y1 - 2002

N2 - Breast cancer frequently leads to incurable bone metastasis. Essential requirements for the development of bone metastasis are cell-cell and cell-matrix interactions, release of bioactive growth factors and cytokines, and removal of large amounts of bone matrix. Matrix metalloproteinases (MMPs) play an important role in all of these processes, but the possibility of using synthetic MMP inhibitors to decrease bone metastasis has received little attention.

AB - Breast cancer frequently leads to incurable bone metastasis. Essential requirements for the development of bone metastasis are cell-cell and cell-matrix interactions, release of bioactive growth factors and cytokines, and removal of large amounts of bone matrix. Matrix metalloproteinases (MMPs) play an important role in all of these processes, but the possibility of using synthetic MMP inhibitors to decrease bone metastasis has received little attention.

KW - Animals

KW - Antineoplastic Agents

KW - Bone Neoplasms

KW - Breast Neoplasms

KW - Cell Survival

KW - Dipeptides

KW - Female

KW - Gene Therapy

KW - Humans

KW - Matrix Metalloproteinases

KW - Mice

KW - Mice, Inbred BALB C

KW - Mice, Nude

KW - Neoplasm Invasiveness

KW - Osteolysis

KW - Phenylalanine

KW - Protease Inhibitors

KW - Thiophenes

KW - Transfection

KW - Transplantation, Heterologous

KW - Tumor Cells, Cultured

M3 - Journal article

C2 - 12060638

SN - 1078-0432

VL - 8

SP - 1932

EP - 1939

JO - Clinical Cancer Research

JF - Clinical Cancer Research

IS - 6

ER -