Systolic heart failure: a prothrombotic state

Olav R de Peuter, Wouter E M Kok, Christian Torp-Pedersen, Harry R Büller, Pieter W Kamphuisen, Olav R de Peuter, Wouter E M Kok, Christian Torp-Pedersen, Harry R Büller, Pieter W Kamphuisen

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    30 Citations (Scopus)

    Abstract

    Systolic heart failure is a common syndrome whose incidence is expected to increase. Several treatment modalities, such as beta-blockers and angiotensin-converting enzyme inhibitors, improve survival. Whether antithrombotic treatment is effective remains to be elucidated, although observations suggest a prothrombotic state in heart failure. This article focuses on this prothrombotic state and discusses the risk of thromboembolic events, pathophysiological mechanisms, and the potential role of anticoagulant treatment.
    Original languageEnglish
    JournalSeminars in Thrombosis and Hemostasis
    Volume35
    Issue number5
    Pages (from-to)497-504
    Number of pages8
    ISSN0094-6176
    DOIs
    Publication statusPublished - 1 Jul 2009

    Bibliographical note

    Keywords: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Anticoagulants; Aspirin; Fibrinolytic Agents; Heart Failure, Systolic; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Prognosis; Pulmonary Embolism; Randomized Controlled Trials as Topic; Receptors, Angiotensin; Renin-Angiotensin System; Thromboembolism; Warfarin

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