Tandem Facial Amphiphiles for Membrane Protein Stabilization

Pil Seok Chae, Kamil Gotfryd, Jennifer Pacyna, Larry J W Miercke, Søren G F Rasmussen, Rebecca A Robbins, Rohini R Rana, Claus Juul Løland, Brian Kobilka, Robert Stroud, Bernadette Byrne, Ulrik Gether, Samuel H Gellman

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81 Citations (Scopus)

Abstract

We describe a new type of synthetic amphiphile that is intended to support biochemical characterization of intrinsic membrane proteins. Members of this new family displayed favorable behavior with four of five membrane proteins tested, and these amphiphiles formed relatively small micelles.
Original languageEnglish
JournalJournal of the American Chemical Society
Volume132
Issue number47
Pages (from-to)16750-2
Number of pages3
ISSN0002-7863
DOIs
Publication statusPublished - 1 Dec 2010

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