Tandem neopentyl glycol maltosides (TNMs) for membrane protein stabilisation

Hyoung Eun Bae, Jonas S Mortensen, Orquidea Ribeiro, Yang Du, Muhammad Ehsan, Brian K Kobilka, Claus J Loland, Bernadette Byrne, Pil Seok Chae

Research output: Contribution to journalJournal articleResearchpeer-review

12 Citations (Scopus)

Abstract

A novel class of detergents, designated tandem neopentyl glycol maltosides (TNMs), were evaluated with four target membrane proteins. The best detergent varied depending on the target, but TNM-C12L and TNM-C11S were notable for their ability to confer increased membrane protein stability compared to DDM. These agents have potential for use in membrane protein research.

Original languageEnglish
JournalChemical communications (Cambridge, England)
Volume52
Issue number81
Pages (from-to)12104-12107
Number of pages4
ISSN1359-7345
DOIs
Publication statusPublished - 4 Oct 2016

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