Temperature Controls Onset and Period of NF-kappa B Oscillations and can Lead to Chaotic Dynamics

Mathias Heltberg, Mads von Borries, Poul Martin Bendix, Lene B. Oddershede, Mogens H. Jensen

Research output: Contribution to journalJournal articleResearchpeer-review

1 Citation (Scopus)
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Abstract

The transcription factor NF-kappa B plays a vital role in the control of the immune system, and following stimulation with TNF-alpha its nuclear concentration shows oscillatory behaviour. How environmental factors, in particular temperature, can control the oscillations and thereby affect gene stimulation is still remains to be resolved question. In this work, we reveal that the period of the oscillations decreases with increasing temperature. We investigate this using a mathematical model, and by applying results from statistical physics, we introduce temperature dependency to all rates, resulting in a remarkable correspondence between model and experiments. Our model predicts how temperature affects downstream protein production and find a crossover, where high affinity genes upregulates at high temperatures. Finally, we show how or that oscillatory temperatures can entrain NF-kappa B oscillations and lead to chaotic dynamics presenting a simple path to chaotic conditions in cellular biology.

Original languageEnglish
Article number910738
JournalFrontiers in Cell and Developmental Biology
Volume10
Number of pages14
ISSN2296-634X
DOIs
Publication statusPublished - 20 Jun 2022

Keywords

  • dynamical systems
  • oscillations
  • gene regulation
  • controllability
  • chaos
  • transcription factors
  • NF-kB
  • CIRCADIAN-RHYTHMS
  • COMPENSATION
  • LOCKING
  • STRESS
  • MODEL

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