The apoptosis linked gene ALG-2 is dysregulated in tumors of various origin and contributes to cancer cell viability

Jonas la Cour; Berit Rahbek Høj; Jens Mollerup; Ronald Simon; Guido Sauter; Martin Werner Berchtold

doi:10.1016/j.molonc.2007.08.002

The apoptosis linked gene ALG-2 is dysregulated in tumors of various origin and contributes to cancer cell viability

Jonas la Cour
, Berit Rahbek Høj
, Jens Mollerup
, Ronald Simon
, Guido Sauter
, Martin Werner Berchtold

Cell Biology and Physiology

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

The apoptosis linked gene-2 (ALG-2), discovered as a proapoptotic calcium binding protein, has recently been found upregulated in lung cancer tissue indicating that this protein may play a role in the pathology of cancer cells and/or may be a tumor marker. Using immunohistochemistry on tissue microarrays we analysed the expression of ALG-2 in 7371 tumor tissue samples of various origin as well as in 749 normal tissue samples. Most notably, ALG-2 was upregulated in mesenchymal tumors. No correlation was found between ALG-2 staining intensity and survival of patients with lung, breast or colon cancer. siRNA mediated ALG-2 downregulation led to a significant reduction in viability of HeLa cells indicating that ALG-2 may contribute to tumor development and expansion.

Original language	English
Journal	Molecular Oncology
Volume	1
Issue number	4
Pages (from-to)	431-439
Number of pages	9
ISSN	1574-7891
DOIs	https://doi.org/10.1016/j.molonc.2007.08.002
Publication status	Published - 2008

Bibliographical note

Keywords: Calcium binding proteins, Tissue microarray, Gene silencing, ALG-2

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@article{907fdaf0dd8511ddb5fc000ea68e967b,

title = "The apoptosis linked gene ALG-2 is dysregulated in tumors of various origin and contributes to cancer cell viability",

abstract = "The apoptosis linked gene-2 (ALG-2), discovered as a proapoptotic calcium binding protein, has recently been found upregulated in lung cancer tissue indicating that this protein may play a role in the pathology of cancer cells and/or may be a tumor marker. Using immunohistochemistry on tissue microarrays we analysed the expression of ALG-2 in 7371 tumor tissue samples of various origin as well as in 749 normal tissue samples. Most notably, ALG-2 was upregulated in mesenchymal tumors. No correlation was found between ALG-2 staining intensity and survival of patients with lung, breast or colon cancer. siRNA mediated ALG-2 downregulation led to a significant reduction in viability of HeLa cells indicating that ALG-2 may contribute to tumor development and expansion.",

author = "\{la Cour\}, Jonas and H{\o}j, \{Berit Rahbek\} and Jens Mollerup and Ronald Simon and Guido Sauter and Berchtold, \{Martin Werner\}",

note = "Keywords: Calcium binding proteins, Tissue microarray, Gene silencing, ALG-2",

year = "2008",

doi = "10.1016/j.molonc.2007.08.002",

language = "English",

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T1 - The apoptosis linked gene ALG-2 is dysregulated in tumors of various origin and contributes to cancer cell viability

AU - la Cour, Jonas

AU - Høj, Berit Rahbek

AU - Mollerup, Jens

AU - Simon, Ronald

AU - Sauter, Guido

AU - Berchtold, Martin Werner

N1 - Keywords: Calcium binding proteins, Tissue microarray, Gene silencing, ALG-2

PY - 2008

Y1 - 2008

N2 - The apoptosis linked gene-2 (ALG-2), discovered as a proapoptotic calcium binding protein, has recently been found upregulated in lung cancer tissue indicating that this protein may play a role in the pathology of cancer cells and/or may be a tumor marker. Using immunohistochemistry on tissue microarrays we analysed the expression of ALG-2 in 7371 tumor tissue samples of various origin as well as in 749 normal tissue samples. Most notably, ALG-2 was upregulated in mesenchymal tumors. No correlation was found between ALG-2 staining intensity and survival of patients with lung, breast or colon cancer. siRNA mediated ALG-2 downregulation led to a significant reduction in viability of HeLa cells indicating that ALG-2 may contribute to tumor development and expansion.

AB - The apoptosis linked gene-2 (ALG-2), discovered as a proapoptotic calcium binding protein, has recently been found upregulated in lung cancer tissue indicating that this protein may play a role in the pathology of cancer cells and/or may be a tumor marker. Using immunohistochemistry on tissue microarrays we analysed the expression of ALG-2 in 7371 tumor tissue samples of various origin as well as in 749 normal tissue samples. Most notably, ALG-2 was upregulated in mesenchymal tumors. No correlation was found between ALG-2 staining intensity and survival of patients with lung, breast or colon cancer. siRNA mediated ALG-2 downregulation led to a significant reduction in viability of HeLa cells indicating that ALG-2 may contribute to tumor development and expansion.

U2 - 10.1016/j.molonc.2007.08.002

DO - 10.1016/j.molonc.2007.08.002

M3 - Journal article

C2 - 19383317

SN - 1574-7891

VL - 1

SP - 431

EP - 439

JO - Molecular Oncology

JF - Molecular Oncology

IS - 4

ER -