Abstract
The tubuloglomerular feedback (TGF) mechanism modulates renal hemodynamics and glomerular filtration rate in individual nephrons. Our study aimed to evaluate the TGF-induced vascular responses by inhibiting Na-K-2Cl co-transporters and sodium-glucose co-transporters in rats. We assessed cortical hemodynamics with high-resolution laser speckle contrast imaging, which enabled the evaluation of blood flow in individual microvessels and analysis of their dynamical patterns in the time-frequency domain. We demonstrated that a systemic administration of furosemide abolishes TGF-mediated hemodynamic responses. Furthermore, we showed that the local microcirculatory blood flow decreased, and the TGF-induced hemodynamic oscillations were sustained but weakened after inhibiting sodium-glucose co-transporters in Sprague-Dawley rats.
Original language | English |
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Article number | e15648 |
Journal | Physiological Reports |
Volume | 11 |
Issue number | 6 |
Number of pages | 13 |
ISSN | 2051-817X |
DOIs | |
Publication status | Published - Mar 2023 |
Bibliographical note
© 2023 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.Keywords
- Rats
- Animals
- Rats, Sprague-Dawley
- Neurovascular Coupling
- Feedback
- Microcirculation
- Glomerular Filtration Rate/physiology
- Sodium/metabolism
- Symporters
- Glucose
- Kidney Tubules/metabolism