The cardioprotective effect of brief acidic reperfusion after ischemia in perfused rat hearts is not mimicked by inhibition of the Na+/H+ exchanger NHE1

Ann-Dorit Andersen; Bo Hjorth Bentzen; H. Salling; Henrik Klingberg; Morten Kanneworff; Morten Grunnet; Stine Helene Falsig Pedersen

doi:10.1159/000331709

The cardioprotective effect of brief acidic reperfusion after ischemia in perfused rat hearts is not mimicked by inhibition of the Na⁺/H⁺ exchanger NHE1

Ann-Dorit Andersen, Bo Hjorth Bentzen, H. Salling, Henrik Klingberg, Morten Kanneworff, Morten Grunnet, Stine Helene Falsig Pedersen

Research output: Contribution to journal › Journal article › Research › peer-review

8 Citations (Scopus)

Abstract

Ischemic postconditioning (PostC), i.e. brief ischemia-reperfusion cycles before full reperfusion, is protective against cardiac ischemia/reperfusion (I/R) injury. Inhibition of the Na(+)/H(+) exchanger NHE1 and delayed intracellular pH-normalization have been proposed to underlie protection by PostC.

Original language	English
Journal	Cellular Physiology and Biochemistry
Volume	28
Issue number	1
Pages (from-to)	13-24
Number of pages	12
ISSN	1015-8987
DOIs	https://doi.org/10.1159/000331709
Publication status	Published - 2011

Keywords

Acids
Amiloride
Animals
Apoptosis
Cells, Cultured
Hydrogen-Ion Concentration
Ischemic Postconditioning
Male
Mitogen-Activated Protein Kinase 8
Mitogen-Activated Protein Kinase 9
Models, Biological
Myocardial Ischemia
Myocardial Reperfusion Injury
Myocytes, Cardiac
Necrosis
Neuroprotective Agents
Proto-Oncogene Proteins c-akt
Rats
Rats, Sprague-Dawley
Sodium-Hydrogen Antiporter
p38 Mitogen-Activated Protein Kinases

Access to Document

10.1159/000331709

Cite this

The cardioprotective effect of brief acidic reperfusion after ischemia in perfused rat hearts is not mimicked by inhibition of the Na⁺/H⁺ exchanger NHE1. / Andersen, Ann-Dorit; Bentzen, Bo Hjorth; Salling, H. et al.
In: Cellular Physiology and Biochemistry, Vol. 28, No. 1, 2011, p. 13-24.

Research output: Contribution to journal › Journal article › Research › peer-review

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abstract = "Ischemic postconditioning (PostC), i.e. brief ischemia-reperfusion cycles before full reperfusion, is protective against cardiac ischemia/reperfusion (I/R) injury. Inhibition of the Na(+)/H(+) exchanger NHE1 and delayed intracellular pH-normalization have been proposed to underlie protection by PostC.",

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author = "Ann-Dorit Andersen and Bentzen, {Bo Hjorth} and H. Salling and Henrik Klingberg and Morten Kanneworff and Morten Grunnet and Pedersen, {Stine Helene Falsig}",

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AU - Andersen, Ann-Dorit

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AU - Salling, H.

AU - Klingberg, Henrik

AU - Kanneworff, Morten

AU - Grunnet, Morten

AU - Pedersen, Stine Helene Falsig

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