The effect of inosine on the spectroscopic properties and crystal structure of a NIR-emitting DNA-stabilized silver nanocluster

Cecilia Cerretani; Mikkel B. Liisberg; Vanessa Ruck; Jiro Kondo; Tom Vosch

doi:10.1039/d2na00325b

The effect of inosine on the spectroscopic properties and crystal structure of a NIR-emitting DNA-stabilized silver nanocluster

Cecilia Cerretani, Mikkel B. Liisberg, Vanessa Ruck, Jiro Kondo, Tom Vosch

Department of Chemistry

Research output: Contribution to journal › Journal article › Research › peer-review

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Abstract

The effect of replacing guanosines with inosines in the two stabilizing strands (5 '-CACCTAGCGA-3 ') of the NIR emissive DNA-Ag16NC was investigated. The spectroscopic behavior of the inosine mutants is position-dependent: when the guanosine in position 7 was exchanged, the nanosecond fluorescence decay time shortened, while having the inosine in position 9 made the decay time longer. Thanks to structural information gained from single crystal X-ray diffraction measurements, it was possible to propose a mechanistic origin for the observed changes.

Original language	English
Journal	Nanoscale Advances
Volume	4
Issue number	15
Pages (from-to)	3212–3217
Number of pages	6
ISSN	2516-0230
DOIs	https://doi.org/10.1039/d2na00325b
Publication status	Published - 20 Jun 2022

Keywords

QUANTUM YIELD
FLUORESCENCE

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10.1039/d2na00325bLicence: CC BY

FulltextFinal published version, 0.98 MBLicence: CC BY

Cite this

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title = "The effect of inosine on the spectroscopic properties and crystal structure of a NIR-emitting DNA-stabilized silver nanocluster",

abstract = "The effect of replacing guanosines with inosines in the two stabilizing strands (5 '-CACCTAGCGA-3 ') of the NIR emissive DNA-Ag16NC was investigated. The spectroscopic behavior of the inosine mutants is position-dependent: when the guanosine in position 7 was exchanged, the nanosecond fluorescence decay time shortened, while having the inosine in position 9 made the decay time longer. Thanks to structural information gained from single crystal X-ray diffraction measurements, it was possible to propose a mechanistic origin for the observed changes.",

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T1 - The effect of inosine on the spectroscopic properties and crystal structure of a NIR-emitting DNA-stabilized silver nanocluster

AU - Cerretani, Cecilia

AU - Liisberg, Mikkel B.

AU - Ruck, Vanessa

AU - Kondo, Jiro

AU - Vosch, Tom

PY - 2022/6/20

Y1 - 2022/6/20

N2 - The effect of replacing guanosines with inosines in the two stabilizing strands (5 '-CACCTAGCGA-3 ') of the NIR emissive DNA-Ag16NC was investigated. The spectroscopic behavior of the inosine mutants is position-dependent: when the guanosine in position 7 was exchanged, the nanosecond fluorescence decay time shortened, while having the inosine in position 9 made the decay time longer. Thanks to structural information gained from single crystal X-ray diffraction measurements, it was possible to propose a mechanistic origin for the observed changes.

AB - The effect of replacing guanosines with inosines in the two stabilizing strands (5 '-CACCTAGCGA-3 ') of the NIR emissive DNA-Ag16NC was investigated. The spectroscopic behavior of the inosine mutants is position-dependent: when the guanosine in position 7 was exchanged, the nanosecond fluorescence decay time shortened, while having the inosine in position 9 made the decay time longer. Thanks to structural information gained from single crystal X-ray diffraction measurements, it was possible to propose a mechanistic origin for the observed changes.

KW - QUANTUM YIELD

KW - FLUORESCENCE

U2 - 10.1039/d2na00325b

DO - 10.1039/d2na00325b

M3 - Journal article

C2 - 36132821

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SP - 3212

EP - 3217

JO - Nanoscale Advances

JF - Nanoscale Advances

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