The effect of sertindole on QTD and TPTE

J Nielsen; M P Andersen; Claus Graff; Jørgen K. Kanters; Thomas Bork Hardahl; J Dybbro; Johannes J. Struijk; J M Meyer; E Toft

doi:10.1111/j.1600-0447.2009.01534.x

The effect of sertindole on QTD and TPTE

J Nielsen, M P Andersen, Claus Graff, Jørgen K. Kanters, Thomas Bork Hardahl, J Dybbro, Johannes J. Struijk, J M Meyer, E Toft

Physiology of circulation, kidney and lung

Research output: Contribution to journal › Journal article › Research › peer-review

32 Citations (Scopus)

Abstract

Recent research suggests that other surrogate markers than QTc, including QTc dispersion and Tpeak-Tend, may better correlate with cardiac arrhythmia risk. While sertindole significantly prolongs the QTc interval, the effects on other markers of arrhythmia risk, such as QTc dispersion and Tpeak-Tend are unknown.

Original language	English
Book series	Acta Psychiatrica Scandinavica. Supplementum
Volume	121
Issue number	5
Pages (from-to)	385-8
Number of pages	4
ISSN	0065-1591
DOIs	https://doi.org/10.1111/j.1600-0447.2009.01534.x
Publication status	Published - 1 May 2010

Keywords

Adult
Antipsychotic Agents
Denmark
Electrocardiography
Female
Heart Rate
Humans
Imidazoles
Indoles
Long QT Syndrome
Male
Middle Aged
Prospective Studies
Safety-Based Drug Withdrawals
Schizophrenia
Signal Processing, Computer-Assisted
Torsades de Pointes

Access to Document

10.1111/j.1600-0447.2009.01534.x

Cite this

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title = "The effect of sertindole on QTD and TPTE",

abstract = "Recent research suggests that other surrogate markers than QTc, including QTc dispersion and Tpeak-Tend, may better correlate with cardiac arrhythmia risk. While sertindole significantly prolongs the QTc interval, the effects on other markers of arrhythmia risk, such as QTc dispersion and Tpeak-Tend are unknown.",

keywords = "Adult, Antipsychotic Agents, Denmark, Electrocardiography, Female, Heart Rate, Humans, Imidazoles, Indoles, Long QT Syndrome, Male, Middle Aged, Prospective Studies, Safety-Based Drug Withdrawals, Schizophrenia, Signal Processing, Computer-Assisted, Torsades de Pointes",

author = "J Nielsen and Andersen, {M P} and Claus Graff and Kanters, {J{\o}rgen K.} and Hardahl, {Thomas Bork} and J Dybbro and Struijk, {Johannes J.} and Meyer, {J M} and E Toft",

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language = "English",

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T1 - The effect of sertindole on QTD and TPTE

AU - Nielsen, J

AU - Andersen, M P

AU - Graff, Claus

AU - Kanters, Jørgen K.

AU - Hardahl, Thomas Bork

AU - Dybbro, J

AU - Struijk, Johannes J.

AU - Meyer, J M

AU - Toft, E

PY - 2010/5/1

Y1 - 2010/5/1

N2 - Recent research suggests that other surrogate markers than QTc, including QTc dispersion and Tpeak-Tend, may better correlate with cardiac arrhythmia risk. While sertindole significantly prolongs the QTc interval, the effects on other markers of arrhythmia risk, such as QTc dispersion and Tpeak-Tend are unknown.

AB - Recent research suggests that other surrogate markers than QTc, including QTc dispersion and Tpeak-Tend, may better correlate with cardiac arrhythmia risk. While sertindole significantly prolongs the QTc interval, the effects on other markers of arrhythmia risk, such as QTc dispersion and Tpeak-Tend are unknown.

KW - Adult

KW - Antipsychotic Agents

KW - Denmark

KW - Electrocardiography

KW - Female

KW - Heart Rate

KW - Humans

KW - Imidazoles

KW - Indoles

KW - Long QT Syndrome

KW - Male

KW - Middle Aged

KW - Prospective Studies

KW - Safety-Based Drug Withdrawals

KW - Schizophrenia

KW - Signal Processing, Computer-Assisted

KW - Torsades de Pointes

U2 - 10.1111/j.1600-0447.2009.01534.x

DO - 10.1111/j.1600-0447.2009.01534.x

M3 - Journal article

C2 - 20085555

VL - 121

SP - 385

EP - 388

JO - Acta Psychiatrica Scandinavica. Supplementum

JF - Acta Psychiatrica Scandinavica. Supplementum

SN - 0065-1591

IS - 5

ER -