Abstract
BACKGROUND: The shift from solitary to social behavior is one of the major evolutionary transitions. Primitively eusocial bumblebees are uniquely placed to illuminate the evolution of highly eusocial insect societies. Bumblebees are also invaluable natural and agricultural pollinators, and there is widespread concern over recent population declines in some species. High-quality genomic data will inform key aspects of bumblebee biology, including susceptibility to implicated population viability threats.
RESULTS: We report the high quality draft genome sequences of Bombus terrestris and Bombus impatiens, two ecologically dominant bumblebees and widely utilized study species. Comparing these new genomes to those of the highly eusocial honeybee Apis mellifera and other Hymenoptera, we identify deeply conserved similarities, as well as novelties key to the biology of these organisms. Some honeybee genome features thought to underpin advanced eusociality are also present in bumblebees, indicating an earlier evolution in the bee lineage. Xenobiotic detoxification and immune genes are similarly depauperate in bumblebees and honeybees, and multiple categories of genes linked to social organization, including development and behavior, show high conservation. Key differences identified include a bias in bumblebee chemoreception towards gustation from olfaction, and striking differences in microRNAs, potentially responsible for gene regulation underlying social and other traits.
CONCLUSIONS: These two bumblebee genomes provide a foundation for post-genomic research on these key pollinators and insect societies. Overall, gene repertoires suggest that the route to advanced eusociality in bees was mediated by many small changes in many genes and processes, and not by notable expansion or depauperation.
| Original language | English |
|---|---|
| Article number | 76 |
| Journal | Genome Biology (Online Edition) |
| Volume | 16 |
| Number of pages | 31 |
| ISSN | 1474-7596 |
| DOIs | |
| Publication status | Published - 2015 |
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The genomes of two key bumblebee species with primitive eusocial organization. / Sadd, Ben M.; Barribeau, Seth M.; Bloch, Guy; de Graaf, Dirk C.; Dearden, Peter; Elsik, Christine G.; Gadau, Jürgen; Grimmelikhuijzen, Cornelis; Hasselmann, Martin; Lozier, Jeffrey D; Robertson, Hugh M; Smagghe, Guy; Stolle, Eckart; Van Vaerenbergh, Matthias; Waterhouse, Robert M; Bornberg-Bauer, Erich; Klasberg, Steffen; Bennett, Anna K; Câmara, Francisco; Guigó, Roderic; Hoff, Katharina; Mariotti, Marco; Munoz-Torres, Monica; Murphy, Terence; Santesmasses, Didac; Amdam, Gro V; Beckers, Matthew; Beye, Martin; Biewer, Matthias; Bitondi, Márcia Mg; Blaxter, Mark L; Bourke, Andrew Fg; Brown, Mark Jf; Buechel, Severine D; Cameron, Rossanah; Cappelle, Kaat; Carolan, James C; Christiaens, Olivier; Ciborowski, Kate L; Clarke, David F; Colgan, Thomas J; Collins, David H; Cridge, Andrew G; Dalmay, Tamas; Dreier, Stephanie; du Plessis, Louis; Duncan, Elizabeth; Erler, Silvio; Evans, Jay; Falcon, Tiago; Flores, Kevin; Freitas, Flávia Cp; Fuchikawa, Taro; Gempe, Tanja; Hartfelder, Klaus; Hauser, Frank; Helbing, Sophie; Humann, Fernanda C; Irvine, Frano; Jermiin, Lars S; Johnson, Claire E; Johnson, Reed M; Jones, Andrew K; Kadowaki, Tatsuhiko; Kidner, Jonathan H; Koch, Vasco; Köhler, Arian; Kraus, F Bernhard; Lattorff, H Michael G; Leask, Megan; Lockett, Gabrielle A; Mallon, Eamonn B; Antonio, David S Marco; Marxer, Monika; Meeus, Ivan; Moritz, Robin Fa; Nair, Ajay; Näpflin, Kathrin; Nissen, Inga; Niu, Jinzhi; Nunes, Francis Mf; Oakeshott, John G; Osborne, Amy; Otte, Marianne; Pinheiro, Daniel G; Rossié, Nina; Rueppell, Olav; Santos, Carolina G; Schmid-Hempel, Regula; Schmitt, Björn D; Schulte, Christina; Simões, Zilá Lp; Soares, Michelle Pm; Swevers, Luc; Winnebeck, Eva C; Wolschin, Florian; Yu, Na; Zdobnov, Evgeny M; Aqrawi, Peshtewani K; Blankenburg, Kerstin P; Coyle, Marcus; Francisco, Liezl; Hernandez, Alvaro G; Holder, Michael; Hudson, Matthew E; Jackson, LaRonda; Jayaseelan, Joy; Joshi, Vandita; Kovar, Christie; Lee, Sandra L; Mata, Robert; Mathew, Tittu; Newsham, Irene F; Ngo, Robin; Okwuonu, Geoffrey; Pham, Christopher; Pu, Ling-Ling; Saada, Nehad; Santibanez, Jireh; Simmons, DeNard; Thornton, Rebecca; Venkat, Aarti; Walden, Kimberly Ko; Wu, Yuan-Qing; Debyser, Griet; Devreese, Bart; Asher, Claire; Blommaert, Julie; Chipman, Ariel D; Chittka, Lars; Fouks, Bertrand; Liu, Jisheng; O'Neill, Meaghan P; Sumner, Seirian; Puiu, Daniela; Qu, Jiaxin; Salzberg, Steven L; Scherer, Steven E; Muzny, Donna M; Richards, Stephen; Robinson, Gene E; Gibbs, Richard A; Schmid-Hempel, Paul; Worley, Kim C.
In: Genome Biology (Online Edition), Vol. 16, 76, 2015.Research output: Contribution to journal › Journal article › Research › peer-review
}
TY - JOUR
T1 - The genomes of two key bumblebee species with primitive eusocial organization
AU - Sadd, Ben M.
AU - Barribeau, Seth M.
AU - Bloch, Guy
AU - de Graaf, Dirk C.
AU - Dearden, Peter
AU - Elsik, Christine G.
AU - Gadau, Jürgen
AU - Grimmelikhuijzen, Cornelis
AU - Hasselmann, Martin
AU - Lozier, Jeffrey D
AU - Robertson, Hugh M
AU - Smagghe, Guy
AU - Stolle, Eckart
AU - Van Vaerenbergh, Matthias
AU - Waterhouse, Robert M
AU - Bornberg-Bauer, Erich
AU - Klasberg, Steffen
AU - Bennett, Anna K
AU - Câmara, Francisco
AU - Guigó, Roderic
AU - Hoff, Katharina
AU - Mariotti, Marco
AU - Munoz-Torres, Monica
AU - Murphy, Terence
AU - Santesmasses, Didac
AU - Amdam, Gro V
AU - Beckers, Matthew
AU - Beye, Martin
AU - Biewer, Matthias
AU - Bitondi, Márcia Mg
AU - Blaxter, Mark L
AU - Bourke, Andrew Fg
AU - Brown, Mark Jf
AU - Buechel, Severine D
AU - Cameron, Rossanah
AU - Cappelle, Kaat
AU - Carolan, James C
AU - Christiaens, Olivier
AU - Ciborowski, Kate L
AU - Clarke, David F
AU - Colgan, Thomas J
AU - Collins, David H
AU - Cridge, Andrew G
AU - Dalmay, Tamas
AU - Dreier, Stephanie
AU - du Plessis, Louis
AU - Duncan, Elizabeth
AU - Erler, Silvio
AU - Evans, Jay
AU - Falcon, Tiago
AU - Flores, Kevin
AU - Freitas, Flávia Cp
AU - Fuchikawa, Taro
AU - Gempe, Tanja
AU - Hartfelder, Klaus
AU - Hauser, Frank
AU - Helbing, Sophie
AU - Humann, Fernanda C
AU - Irvine, Frano
AU - Jermiin, Lars S
AU - Johnson, Claire E
AU - Johnson, Reed M
AU - Jones, Andrew K
AU - Kadowaki, Tatsuhiko
AU - Kidner, Jonathan H
AU - Koch, Vasco
AU - Köhler, Arian
AU - Kraus, F Bernhard
AU - Lattorff, H Michael G
AU - Leask, Megan
AU - Lockett, Gabrielle A
AU - Mallon, Eamonn B
AU - Antonio, David S Marco
AU - Marxer, Monika
AU - Meeus, Ivan
AU - Moritz, Robin Fa
AU - Nair, Ajay
AU - Näpflin, Kathrin
AU - Nissen, Inga
AU - Niu, Jinzhi
AU - Nunes, Francis Mf
AU - Oakeshott, John G
AU - Osborne, Amy
AU - Otte, Marianne
AU - Pinheiro, Daniel G
AU - Rossié, Nina
AU - Rueppell, Olav
AU - Santos, Carolina G
AU - Schmid-Hempel, Regula
AU - Schmitt, Björn D
AU - Schulte, Christina
AU - Simões, Zilá Lp
AU - Soares, Michelle Pm
AU - Swevers, Luc
AU - Winnebeck, Eva C
AU - Wolschin, Florian
AU - Yu, Na
AU - Zdobnov, Evgeny M
AU - Aqrawi, Peshtewani K
AU - Blankenburg, Kerstin P
AU - Coyle, Marcus
AU - Francisco, Liezl
AU - Hernandez, Alvaro G
AU - Holder, Michael
AU - Hudson, Matthew E
AU - Jackson, LaRonda
AU - Jayaseelan, Joy
AU - Joshi, Vandita
AU - Kovar, Christie
AU - Lee, Sandra L
AU - Mata, Robert
AU - Mathew, Tittu
AU - Newsham, Irene F
AU - Ngo, Robin
AU - Okwuonu, Geoffrey
AU - Pham, Christopher
AU - Pu, Ling-Ling
AU - Saada, Nehad
AU - Santibanez, Jireh
AU - Simmons, DeNard
AU - Thornton, Rebecca
AU - Venkat, Aarti
AU - Walden, Kimberly Ko
AU - Wu, Yuan-Qing
AU - Debyser, Griet
AU - Devreese, Bart
AU - Asher, Claire
AU - Blommaert, Julie
AU - Chipman, Ariel D
AU - Chittka, Lars
AU - Fouks, Bertrand
AU - Liu, Jisheng
AU - O'Neill, Meaghan P
AU - Sumner, Seirian
AU - Puiu, Daniela
AU - Qu, Jiaxin
AU - Salzberg, Steven L
AU - Scherer, Steven E
AU - Muzny, Donna M
AU - Richards, Stephen
AU - Robinson, Gene E
AU - Gibbs, Richard A
AU - Schmid-Hempel, Paul
AU - Worley, Kim C
PY - 2015
Y1 - 2015
N2 - BACKGROUND: The shift from solitary to social behavior is one of the major evolutionary transitions. Primitively eusocial bumblebees are uniquely placed to illuminate the evolution of highly eusocial insect societies. Bumblebees are also invaluable natural and agricultural pollinators, and there is widespread concern over recent population declines in some species. High-quality genomic data will inform key aspects of bumblebee biology, including susceptibility to implicated population viability threats.RESULTS: We report the high quality draft genome sequences of Bombus terrestris and Bombus impatiens, two ecologically dominant bumblebees and widely utilized study species. Comparing these new genomes to those of the highly eusocial honeybee Apis mellifera and other Hymenoptera, we identify deeply conserved similarities, as well as novelties key to the biology of these organisms. Some honeybee genome features thought to underpin advanced eusociality are also present in bumblebees, indicating an earlier evolution in the bee lineage. Xenobiotic detoxification and immune genes are similarly depauperate in bumblebees and honeybees, and multiple categories of genes linked to social organization, including development and behavior, show high conservation. Key differences identified include a bias in bumblebee chemoreception towards gustation from olfaction, and striking differences in microRNAs, potentially responsible for gene regulation underlying social and other traits.CONCLUSIONS: These two bumblebee genomes provide a foundation for post-genomic research on these key pollinators and insect societies. Overall, gene repertoires suggest that the route to advanced eusociality in bees was mediated by many small changes in many genes and processes, and not by notable expansion or depauperation.
AB - BACKGROUND: The shift from solitary to social behavior is one of the major evolutionary transitions. Primitively eusocial bumblebees are uniquely placed to illuminate the evolution of highly eusocial insect societies. Bumblebees are also invaluable natural and agricultural pollinators, and there is widespread concern over recent population declines in some species. High-quality genomic data will inform key aspects of bumblebee biology, including susceptibility to implicated population viability threats.RESULTS: We report the high quality draft genome sequences of Bombus terrestris and Bombus impatiens, two ecologically dominant bumblebees and widely utilized study species. Comparing these new genomes to those of the highly eusocial honeybee Apis mellifera and other Hymenoptera, we identify deeply conserved similarities, as well as novelties key to the biology of these organisms. Some honeybee genome features thought to underpin advanced eusociality are also present in bumblebees, indicating an earlier evolution in the bee lineage. Xenobiotic detoxification and immune genes are similarly depauperate in bumblebees and honeybees, and multiple categories of genes linked to social organization, including development and behavior, show high conservation. Key differences identified include a bias in bumblebee chemoreception towards gustation from olfaction, and striking differences in microRNAs, potentially responsible for gene regulation underlying social and other traits.CONCLUSIONS: These two bumblebee genomes provide a foundation for post-genomic research on these key pollinators and insect societies. Overall, gene repertoires suggest that the route to advanced eusociality in bees was mediated by many small changes in many genes and processes, and not by notable expansion or depauperation.
U2 - 10.1186/s13059-015-0623-3
DO - 10.1186/s13059-015-0623-3
M3 - Journal article
C2 - 25908251
VL - 16
JO - Genome Biology (Online Edition)
JF - Genome Biology (Online Edition)
SN - 1474-7596
M1 - 76
ER -