The one health problem of azole resistance in Aspergillus fumigatus: current insights and future research agenda

Paul E. Verweij; John A. Lucas; Maiken C. Arendrup; Paul Bowyer; Arjen J.F. Brinkmann; David W. Denning; Paul S. Dyer; Matthew C. Fisher; Petra L. Geenen; Ulrich Gisi; Dietrich Hermann; Andre Hoogendijk; Eric Kiers; Katrien Lagrou; Willem J.G. Melchers; Johanna Rhodes; Anton G. Rietveld; Sijmen E. Schoustra; Klaus Stenzel; Bas J. Zwaan; Bart A. Fraaije

doi:10.1016/j.fbr.2020.10.003

The one health problem of azole resistance in Aspergillus fumigatus: current insights and future research agenda

Paul E. Verweij^*, John A. Lucas, Maiken C. Arendrup, Paul Bowyer, Arjen J.F. Brinkmann, David W. Denning, Paul S. Dyer, Matthew C. Fisher, Petra L. Geenen, Ulrich Gisi, Dietrich Hermann, Andre Hoogendijk, Eric Kiers, Katrien Lagrou, Willem J.G. Melchers, Johanna Rhodes, Anton G. Rietveld, Sijmen E. Schoustra, Klaus Stenzel, Bas J. ZwaanBart A. Fraaije

^*Corresponding author for this work

Research output: Contribution to journal › Review › Research › peer-review

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Abstract

Azole resistance is a concern for the management of diseases caused by Aspergillus fumigatus in humans. Azole fungicide use in the environment has been identified as a possible cause for development of resistance, which increases the complexity and number of stakeholders involved in this emerging problem. A workshop was held in Amsterdam early 2019 in which stakeholders, including medical and agricultural researchers, representatives from the government, public health, fungicide producers and end-users, reviewed the current evidence supporting environmental selection for resistance and to discuss which research and measures are needed to retain the effectiveness of the azole class for environmental and medical applications. This paper provides an overview of the latest insights and understanding of azole resistance development in the clinical setting and the wider environment. A One Health problem approach was undertaken to list and prioritize which research will be needed to provide missing evidence and to enable preventive interventions.

Original language	English
Journal	Fungal Biology Reviews
Volume	34
Issue number	4
Pages (from-to)	202-214
Number of pages	13
ISSN	1749-4613
DOIs	https://doi.org/10.1016/j.fbr.2020.10.003
Publication status	Published - 2020

Keywords

Aspergillus fumigatus
Azole resistance
Demethylase inhibitor
Expert meeting
Fungicide

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Cite this

Verweij, P. E., Lucas, J. A., Arendrup, M. C., Bowyer, P., Brinkmann, A. J. F., Denning, D. W., Dyer, P. S., Fisher, M. C., Geenen, P. L., Gisi, U., Hermann, D., Hoogendijk, A., Kiers, E., Lagrou, K., Melchers, W. J. G., Rhodes, J., Rietveld, A. G., Schoustra, S. E., Stenzel, K., ... Fraaije, B. A. (2020). The one health problem of azole resistance in Aspergillus fumigatus: current insights and future research agenda. Fungal Biology Reviews, 34(4), 202-214. https://doi.org/10.1016/j.fbr.2020.10.003

The one health problem of azole resistance in Aspergillus fumigatus : current insights and future research agenda. / Verweij, Paul E.; Lucas, John A.; Arendrup, Maiken C.; Bowyer, Paul; Brinkmann, Arjen J.F.; Denning, David W.; Dyer, Paul S.; Fisher, Matthew C.; Geenen, Petra L.; Gisi, Ulrich; Hermann, Dietrich; Hoogendijk, Andre; Kiers, Eric; Lagrou, Katrien; Melchers, Willem J.G.; Rhodes, Johanna; Rietveld, Anton G.; Schoustra, Sijmen E.; Stenzel, Klaus; Zwaan, Bas J.; Fraaije, Bart A.

In: Fungal Biology Reviews, Vol. 34, No. 4, 2020, p. 202-214.

Research output: Contribution to journal › Review › Research › peer-review

Verweij, PE, Lucas, JA, Arendrup, MC, Bowyer, P, Brinkmann, AJF, Denning, DW, Dyer, PS, Fisher, MC, Geenen, PL, Gisi, U, Hermann, D, Hoogendijk, A, Kiers, E, Lagrou, K, Melchers, WJG, Rhodes, J, Rietveld, AG, Schoustra, SE, Stenzel, K, Zwaan, BJ & Fraaije, BA 2020, 'The one health problem of azole resistance in Aspergillus fumigatus: current insights and future research agenda', Fungal Biology Reviews, vol. 34, no. 4, pp. 202-214. https://doi.org/10.1016/j.fbr.2020.10.003

Verweij, Paul E. ; Lucas, John A. ; Arendrup, Maiken C. ; Bowyer, Paul ; Brinkmann, Arjen J.F. ; Denning, David W. ; Dyer, Paul S. ; Fisher, Matthew C. ; Geenen, Petra L. ; Gisi, Ulrich ; Hermann, Dietrich ; Hoogendijk, Andre ; Kiers, Eric ; Lagrou, Katrien ; Melchers, Willem J.G. ; Rhodes, Johanna ; Rietveld, Anton G. ; Schoustra, Sijmen E. ; Stenzel, Klaus ; Zwaan, Bas J. ; Fraaije, Bart A. / The one health problem of azole resistance in Aspergillus fumigatus : current insights and future research agenda. In: Fungal Biology Reviews. 2020 ; Vol. 34, No. 4. pp. 202-214.

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