The post-transcriptional operon

Scott A. Tenenbaum, Jan Christiansen, Henrik Nielsen

Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

11 Citations (Scopus)

Abstract

A post-transcriptional operon is a set of monocistronic mRNAs encoding functionally related proteins that are co-regulated by a group of RNA-binding proteins and/or small non-coding RNAs so that protein expression is coordinated at the post-transcriptional level. The post-transcriptional operon model (PTO) is used to describe data from an assortment of methods (e.g. RIP-Chip, CLIP-Chip, miRNA profiling, ribosome profiling) that globally address the functionality of mRNA. Several examples of post-transcriptional operons have been documented in the literature and demonstrate the usefulness of the model in identifying new participants in cellular pathways as well as in deepening our understanding of cellular responses.
Original languageEnglish
Title of host publicationRNA : methods and protocols
EditorsHenrik Nielsen
Number of pages9
PublisherSpringer
Publication date2011
Pages237-245
Chapter16
ISBN (Print)978-1-58829-913-0
ISBN (Electronic)978-1-59745-248-9
DOIs
Publication statusPublished - 2011
SeriesMethods in Molecular Biology
ISSN1064-3745

Keywords

  • Gene Expression Regulation
  • Models, Genetic
  • RNA, Messenger
  • Ribonucleoproteins

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