Abstract
Purpose of review Cognitive decline and late-onset dementia pose significant challenges in aging societies, and many dementia cases could be prevented or delayed through modification of associated risk factors, many of which are tied to cardiovascular and metabolic dysfunction. As individuals age, the blood-brain barrier becomes more permeable, easing the exchange of molecules between the bloodstream and the brain. Consequently, blood-based biological markers (so-called biomarkers) provide a minimally invasive and accessible means of accessing molecular changes associated with aging and neurodegeneration. Recent findings Circulating free fatty acids, also called nonesterified fatty acids (NEFAs), and sphingolipids are associated with cardiovascular disease, insulin resistance, and diabetes; thus, could be promising candidates as biomarkers for cognitive decline and dementia. Summary The opportunity to study such minimally invasive biomarkers further opens up potential new avenues for improved understanding of the underlying biology of diseases of the brain.
Original language | English |
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Journal | Current Opinion in Lipidology |
Volume | 36 |
Issue number | 1 |
Pages (from-to) | 27-37 |
Number of pages | 11 |
ISSN | 0957-9672 |
DOIs | |
Publication status | Published - 2025 |
Bibliographical note
Publisher Copyright:Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.
Keywords
- cognitive decline
- dementia
- nonesterified fatty acids
- sphingolipids