The Rise of Adaptive Platform Trials in Critical Care

Anders Granholm (Member of author collaboration), Morten Hylander Møller (Member of author collaboration), Anders Perner (Member of author collaboration), The PRACTICAL, PANTHER, TRAITS, INCEPT, and REMAP-CAP investigators

Research output: Contribution to journalJournal articleResearchpeer-review

6 Citations (Scopus)

Abstract

As durable learning research systems, adaptive platform trials represent a transformative new approach to accelerating clinical evaluation and discovery in critical care. This Perspective provides a brief introduction to the concept of adaptive platform trials, describes several established and emerging platforms in critical care, and surveys some opportunities and challenges for their implementation and impact.

Original languageEnglish
JournalAmerican Journal of Respiratory and Critical Care Medicine
Volume209
Issue number5
Pages (from-to)491-496
Number of pages6
ISSN1073-449X
DOIs
Publication statusPublished - 2024

Bibliographical note

Publisher Copyright:
© 2024 American Thoracic Society. All rights reserved.

Keywords

  • adaptive design
  • critical care
  • platform trials

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