The Role of a Colon-in-Continuity in Short Bowel Syndrome

Astrid Verbiest, Palle Bekker Jeppesen, Francisca Joly, Tim Vanuytsel*

*Corresponding author for this work

Research output: Contribution to journalReviewResearchpeer-review

12 Citations (Scopus)
7 Downloads (Pure)

Abstract

Short bowel syndrome (SBS) is a rare gastrointestinal condition that is defined as having less than 200 cm of remaining small intestine. SBS results from extensive surgical resection and is associated with a high risk for intestinal failure (IF) with a need for parenteral support (PS). Depending on the region of intestinal resection, three different main anatomy types can be distinguished from each other. In this review, we synthesize the current knowledge on the role of the colon in the setting of SBS-IF with a colon-in-continuity (SBS-IF-CiC), e.g., by enhancing the degree of intestinal adaptation, energy salvage, and the role of the microbiota. In addition, the effect of the disease-modifying treatment with glucagon-like peptide-2 (GLP-2) analogs in SBS-IF-CiC and how it differs from patients without a colon will be discussed. Overall, the findings explained in this review highlight the importance of preservation of the colon in SBS-IF.

Original languageEnglish
Article number628
JournalNutrients
Volume15
Issue number3
Number of pages13
ISSN2072-6643
DOIs
Publication statusPublished - 2023

Bibliographical note

Publisher Copyright:
© 2023 by the authors.

Keywords

  • colon-in-continuity
  • glucagon-like peptide-2 analogs
  • intestinal adaptation
  • intestinal failure
  • parenteral support
  • short bowel syndrome

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