Abstract
Psychedelic 5-hydroxytryptamine 2A receptor (5-HT2AR) agonists are showing promise in the treatment of psychiatric disorders, such as treatment-resistant depression and anxiety. Human studies suggest that enhanced cognitive flexibility may contribute to their clinical efficacy. Both improvement and impairment of cognitive flexibility has been reported with 5-HT2AR ligands, making the link between 5-HT2AR pharmacology and cognitive flexibility equivocal. We tested the selective 5-HT2AR agonist 25CN-NBOH in healthy male C57BL/6JOlaHsd mice in a touchscreen-based mouse reversal learning test. No effects were observed on acquisition of the new stimulus-reward contingency, learning errors, or perseverative responses during reversal. Our results suggest that 25CN-NBOH does not affect reversal learning in the schedule used in this study.
Original language | English |
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Journal | Behavioural Pharmacology |
Volume | 32 |
Issue number | 5 |
Pages (from-to) | 448-452 |
ISSN | 0955-8810 |
DOIs | |
Publication status | Published - 2021 |
Keywords
- 25CN-NBOH
- cognitive flexibility
- 5-HT2A receptor
- psychedelic
- reversal learning
- serotonin