The structure of the serotonin system: A PET imaging study

Vincent Beliveau; Brice Ozenne; Stephen Strother; Douglas N. Greve; Claus Svarer; Gitte Moos Knudsen; Melanie Ganz

doi:10.1016/j.neuroimage.2019.116240

The structure of the serotonin system: A PET imaging study

Vincent Beliveau, Brice Ozenne, Stephen Strother, Douglas N. Greve, Claus Svarer, Gitte Moos Knudsen, Melanie Ganz^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › Research › peer-review

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Abstract

The human brain atlas of the serotonin (5-HT) system does not conform with commonly used parcellations of neocortex, since the spatial distribution of homogeneous 5-HT receptors and transporter is not aligned with such brain regions. This discrepancy indicates that a neocortical parcellation specific to the 5-HT system is needed. We first outline issues with an existing parcellation of the 5-HT system, and present an alternative parcellation derived from brain MR- and high-resolution PET images of five different 5-HT targets from 210 healthy controls. We then explore how well this new 5-HT parcellation can explain mRNA levels of all 5-HT genes. The parcellation derived here represents a characterization of the 5-HT system which is more stable and explains the underlying 5-HT molecular imaging data better than other atlases, and may hence be more sensitive to capture region-specific changes modulated by 5-HT.

Original language	English
Article number	116240
Journal	NeuroImage
Volume	205
ISSN	1053-8119
DOIs	https://doi.org/10.1016/j.neuroimage.2019.116240
Publication status	Published - 2020

Keywords

Clustering
MRI
mRNA
PET
Serotonin
Structure

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title = "The structure of the serotonin system: A PET imaging study",

abstract = "The human brain atlas of the serotonin (5-HT) system does not conform with commonly used parcellations of neocortex, since the spatial distribution of homogeneous 5-HT receptors and transporter is not aligned with such brain regions. This discrepancy indicates that a neocortical parcellation specific to the 5-HT system is needed. We first outline issues with an existing parcellation of the 5-HT system, and present an alternative parcellation derived from brain MR- and high-resolution PET images of five different 5-HT targets from 210 healthy controls. We then explore how well this new 5-HT parcellation can explain mRNA levels of all 5-HT genes. The parcellation derived here represents a characterization of the 5-HT system which is more stable and explains the underlying 5-HT molecular imaging data better than other atlases, and may hence be more sensitive to capture region-specific changes modulated by 5-HT.",

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T2 - A PET imaging study

AU - Beliveau, Vincent

AU - Ozenne, Brice

AU - Strother, Stephen

AU - Greve, Douglas N.

AU - Svarer, Claus

AU - Knudsen, Gitte Moos

AU - Ganz, Melanie

PY - 2020

Y1 - 2020

N2 - The human brain atlas of the serotonin (5-HT) system does not conform with commonly used parcellations of neocortex, since the spatial distribution of homogeneous 5-HT receptors and transporter is not aligned with such brain regions. This discrepancy indicates that a neocortical parcellation specific to the 5-HT system is needed. We first outline issues with an existing parcellation of the 5-HT system, and present an alternative parcellation derived from brain MR- and high-resolution PET images of five different 5-HT targets from 210 healthy controls. We then explore how well this new 5-HT parcellation can explain mRNA levels of all 5-HT genes. The parcellation derived here represents a characterization of the 5-HT system which is more stable and explains the underlying 5-HT molecular imaging data better than other atlases, and may hence be more sensitive to capture region-specific changes modulated by 5-HT.

AB - The human brain atlas of the serotonin (5-HT) system does not conform with commonly used parcellations of neocortex, since the spatial distribution of homogeneous 5-HT receptors and transporter is not aligned with such brain regions. This discrepancy indicates that a neocortical parcellation specific to the 5-HT system is needed. We first outline issues with an existing parcellation of the 5-HT system, and present an alternative parcellation derived from brain MR- and high-resolution PET images of five different 5-HT targets from 210 healthy controls. We then explore how well this new 5-HT parcellation can explain mRNA levels of all 5-HT genes. The parcellation derived here represents a characterization of the 5-HT system which is more stable and explains the underlying 5-HT molecular imaging data better than other atlases, and may hence be more sensitive to capture region-specific changes modulated by 5-HT.

KW - Clustering

KW - MRI

KW - mRNA

KW - PET

KW - Serotonin

KW - Structure

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ER -

The structure of the serotonin system: A PET imaging study

Abstract

Keywords

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