Abstract
The syntheses of monodisperse lysine dendrimers, capped with two to sixty-four mono-, di- and tri-α-d-mannopyranosyl residues are described. These syntheses used reactive N-hydroxysuccinimide esters to ensure complete reaction of dendrimer amines with the mannosylating reagents. The purities of the dendrimers were established by RP-HPLC and MALDI-TOF mass spectrometry and were found to be excellent. The relative ability of these glycodendrimers to induce dendritic cell maturation was measured, however, no significant trends were observed.
Original language | English |
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Journal | Tetrahedron |
Volume | 65 |
Issue number | 15 |
Pages (from-to) | 2939-2950 |
Number of pages | 12 |
ISSN | 0040-4020 |
DOIs | |
Publication status | Published - 11 Apr 2009 |
Bibliographical note
Funding Information:The authors gratefully acknowledge the assistance of Prof. Robin Ferrier in the preparation of this manuscript, Starpharma ( www.starpharma.com ) for providing the lysine dendrimer starting materials and financial support from the Foundation for Research Science and Technology, New Zealand, Contract C08X0303.