Theoretical Considerations in Developing Amorphous Solid Dispersions

Riikka Laitinen, Petra Alexandra Priemel, Sachin Surwase, Kirsten Graeser, Clare J. Strachan, Holger Grohganz, Thomas Rades

Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

Abstract

Before pursuing the laborious route of amorphous solid dispersion formulation and development, which is the topic of many of the subsequent chapters in this book, the formulation scientist would benefit from a priori knowledge whether the amorphous route is a viable one for a given drug and how much solubility improvement, and hence increase in bioavailability, can be expected, and what forms of solid dispersion have been developed in the past. In this chapter, we therefore initially define the various forms of solid dispersions, and then go on to discuss properties of pure drugs with respect to their glass-forming ability and glass stability. In the main parts of this chapter, we review theoretical approaches to determine amorphous drug polymer miscibility and crystalline drug polymer solubility, as a prerequisite to develop amorphous solid dispersions (glass solutions).
Original languageEnglish
Title of host publicationAmorphous Solid Dispersions - Theory and Practice
EditorsNavnit Shah, Harpreet Sandhu, Duk Soon Choi, Hitesh Chokshi, A. Waseem Malick
Number of pages56
Place of PublicationNew York
PublisherSpringer Science+Business Media
Publication date2014
Pages35-90
Chapter2
ISBN (Print)978-1-4939-1597-2
ISBN (Electronic)978-1-4939-1598-9
DOIs
Publication statusPublished - 2014

Cite this