Tipping the balance: New insights into stromal regulation of cancer

Joana Leitão Castro; Janine Terra Erler

doi:10.1016/j.ccell.2022.11.011

Tipping the balance: New insights into stromal regulation of cancer

Joana Leitão Castro, Janine Terra Erler^*

^*Corresponding author for this work

Research output: Contribution to journal › Comment/debate › Research › peer-review

Abstract

Desmoplastic extracellular matrix (ECM) exerts a seemingly paradoxical role in cancer, restricting or promoting progression. Two recent back-to-back Nature reports shed light on this conundrum, revealing the role of different hepatic stellate cell (HSC) populations and different collagen I cleavage states in directing the progression of cancer.

Original language	English
Journal	Cancer Cell
Volume	40
Issue number	12
Pages (from-to)	1467-1469
Number of pages	3
ISSN	1535-6108
DOIs	https://doi.org/10.1016/j.ccell.2022.11.011
Publication status	Published - 2022

Bibliographical note

Publisher Copyright:
© 2022 Elsevier Inc.

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10.1016/j.ccell.2022.11.011

Cite this

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title = "Tipping the balance: New insights into stromal regulation of cancer",

abstract = "Desmoplastic extracellular matrix (ECM) exerts a seemingly paradoxical role in cancer, restricting or promoting progression. Two recent back-to-back Nature reports shed light on this conundrum, revealing the role of different hepatic stellate cell (HSC) populations and different collagen I cleavage states in directing the progression of cancer.",

author = "Castro, {Joana Leit{\~a}o} and Erler, {Janine Terra}",

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AB - Desmoplastic extracellular matrix (ECM) exerts a seemingly paradoxical role in cancer, restricting or promoting progression. Two recent back-to-back Nature reports shed light on this conundrum, revealing the role of different hepatic stellate cell (HSC) populations and different collagen I cleavage states in directing the progression of cancer.

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DO - 10.1016/j.ccell.2022.11.011

M3 - Comment/debate

C2 - 36513048

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SN - 1535-6108

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