Topoisomerase 1(TOP1) gene copy number in stage III colorectal cancer patients and its relation to prognosis

Maria Unni Koefoed Rømer, Sune Boris Nygård, Ib Jarle Christensen, Signe Lykke Nielsen, Kirsten Vang Nielsen, Sven Müller, David Hersi Smith, Ben Vainer, Hans Jørgen Nielsen, Nils Brünner

Research output: Contribution to journalJournal articleResearchpeer-review

21 Citations (Scopus)

Abstract

A Topoisomerase 1 (Top1) poison is frequently included in the treatment regimens for metastatic colorectal cancer (mCRC). However, no predictive biomarkers for Top1 poisons are available. We here report a study on the TOP1 gene copy number in CRC patients and its association with patient prognosis and tumor cell proliferation.
Original languageEnglish
JournalMolecular Oncology
Volume7
Issue number1
Pages (from-to)101-111
Number of pages11
ISSN1574-7891
DOIs
Publication statusPublished - 2013

Keywords

  • Former LIFE faculty

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