TY - JOUR
T1 - Torque-Teno virus viral load as a potential endogenous marker of immune function in solid organ transplantation
AU - Rezahosseini, Omid
AU - Drabe, Camilla Heldbjerg
AU - Sørensen, Søren Schwartz
AU - Rasmussen, Allan
AU - Perch, Michael
AU - Ostrowski, Sisse Rye
AU - Nielsen, Susanne Dam
PY - 2019/7
Y1 - 2019/7
N2 - Solid organ transplantation (SOT) recipients receive immunosuppressive therapy to avoid rejection of the transplanted organ. Immunosuppressive therapy increases the risk of infections. However, no existing marker reliably reveals the status of the immune function in SOT recipients. Torque-Teno virus or Transfusion-transmitted virus (TTV) has gained attention as a possible endogenous marker of the immune function. TTV is a non-enveloped, circular single strand DNA virus, and it may be considered a part of the human virome. In a bidirectional relationship, the immune system detects TTV and TTV may also modulate the activity of immune system. These characteristics have made the virus a possible candidate indicator of immune function. In this systematic review, we describe the role and potential function of TTV viral load as an endogenous marker of the immune function and consequently the level of immune suppression in SOT recipients.
AB - Solid organ transplantation (SOT) recipients receive immunosuppressive therapy to avoid rejection of the transplanted organ. Immunosuppressive therapy increases the risk of infections. However, no existing marker reliably reveals the status of the immune function in SOT recipients. Torque-Teno virus or Transfusion-transmitted virus (TTV) has gained attention as a possible endogenous marker of the immune function. TTV is a non-enveloped, circular single strand DNA virus, and it may be considered a part of the human virome. In a bidirectional relationship, the immune system detects TTV and TTV may also modulate the activity of immune system. These characteristics have made the virus a possible candidate indicator of immune function. In this systematic review, we describe the role and potential function of TTV viral load as an endogenous marker of the immune function and consequently the level of immune suppression in SOT recipients.
KW - Immunosuppression
KW - Infection
KW - Organ transplantation
KW - Rejection
KW - Torque Teno virus
U2 - 10.1016/j.trre.2019.03.004
DO - 10.1016/j.trre.2019.03.004
M3 - Review
C2 - 30981537
AN - SCOPUS:85064073378
VL - 33
SP - 137
EP - 144
JO - Transplantation Reviews
JF - Transplantation Reviews
SN - 0955-470X
IS - 3
ER -