Towards physico-relevant dissolution testing: The importance of solid-state analysis in dissolution

Jaakko Aaltonen*, Thomas Rades

*Corresponding author for this work

Research output: Contribution to journalComment/debateResearchpeer-review

48 Citations (Scopus)

Abstract

Polymorphism and other solid-state phenomena can have effects on many physicochemical properties of pharmaceuticals. In this commentary, some aspects of solid-state pharmaceutics that are important to dissolution testing are highlighted. Examples of how solid-state analysis can be used to aid interpretation of dissolution results are also reviewed. We suggest the term physico-relevant dissolution testing to describe the combination of dissolution testing with solid-state analysis.

Original languageEnglish
JournalDissolution Technologies
Volume16
Issue number2
Pages (from-to)47-54
Number of pages8
ISSN1521-298X
DOIs
Publication statusPublished - May 2009

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