Towards physico-relevant dissolution testing: The importance of solid-state analysis in dissolution

Jaakko Aaltonen; Thomas Rades

doi:10.14227/DT160209P47

Towards physico-relevant dissolution testing: The importance of solid-state analysis in dissolution

Jaakko Aaltonen^*, Thomas Rades

^*Corresponding author for this work

Pharmaceuticals, processes and products

Research output: Contribution to journal › Comment/debate › Research › peer-review

48 Citations (Scopus)

Abstract

Polymorphism and other solid-state phenomena can have effects on many physicochemical properties of pharmaceuticals. In this commentary, some aspects of solid-state pharmaceutics that are important to dissolution testing are highlighted. Examples of how solid-state analysis can be used to aid interpretation of dissolution results are also reviewed. We suggest the term physico-relevant dissolution testing to describe the combination of dissolution testing with solid-state analysis.

Original language	English
Journal	Dissolution Technologies
Volume	16
Issue number	2
Pages (from-to)	47-54
Number of pages	8
ISSN	1521-298X
DOIs	https://doi.org/10.14227/DT160209P47
Publication status	Published - May 2009

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abstract = "Polymorphism and other solid-state phenomena can have effects on many physicochemical properties of pharmaceuticals. In this commentary, some aspects of solid-state pharmaceutics that are important to dissolution testing are highlighted. Examples of how solid-state analysis can be used to aid interpretation of dissolution results are also reviewed. We suggest the term physico-relevant dissolution testing to describe the combination of dissolution testing with solid-state analysis.",

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AB - Polymorphism and other solid-state phenomena can have effects on many physicochemical properties of pharmaceuticals. In this commentary, some aspects of solid-state pharmaceutics that are important to dissolution testing are highlighted. Examples of how solid-state analysis can be used to aid interpretation of dissolution results are also reviewed. We suggest the term physico-relevant dissolution testing to describe the combination of dissolution testing with solid-state analysis.

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Towards physico-relevant dissolution testing: The importance of solid-state analysis in dissolution

Abstract

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