Tramadol does not improve performance or impair motor function in trained cyclists

Jacob Bejder, Andreas Breenfeldt Andersen, Thomas Christian Bonne, Jacob Feder Piil, Linn Camilla Hauan Hagen, Yvette Dehnes, Kasper Hvid Eibye, Lars Nybo, Nikolai Baastrup Nordsborg*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

11 Citations (Scopus)
27 Downloads (Pure)

Abstract

Purpose: To investigate the hypothesis that a therapeutic oral dose of Tramadol improves cycling time trial performance and compromises motor-cognitive performance in highly trained cyclists.

Methods: Following two familiarization trials, 16 highly trained cyclists completed a preloaded time trial (1 hour at 60 % of peak power followed by a 15 km time trial) after ingestion of 100 mg Tramadol or placebo in a double-blind placebo-controlled counterbalanced cross-over design separated by at least 4 days wash-out. Visuo-motor tracking and math tasks were completed during the preload (n=10) to evaluate effects on cognition and fine motor performance.

Results: Time trial mean power output (298±42 W vs. 294±44 W) and performance (1474±77 s vs. 1483±85 s) were similar with Tramadol and placebo treatment, respectively. In addition, there were no differences in perceived exertion, reported pain, blood pH, lactate or HCO3 concentrations across trials. Heart rate was higher (P<0.001) during the Tramadol time trial (171±8 bpm) compared to placebo (167±9 bpm). None of the combined motor-cognitive tasks were impaired by Tramadol ingestion, in fact fine motor performance was slightly improved (P<0.05) in the Tramadol trial compared to placebo.

Conclusion: In highly trained cyclists, ingestion of 100 mg Tramadol does not improve performance in a 15 km cycling time trial that was completed after a one hour preload at 60 % peak power. Additionally, a therapeutic dose of Tramadol does not compromise complex motor-cognitive or simple fine motor performances.

Original languageEnglish
JournalMedicine and Science in Sports and Exercise
Volume52
Issue number5
Pages (from-to)1169-1175
Number of pages7
ISSN0195-9131
DOIs
Publication statusPublished - 2020

Keywords

  • Faculty of Science
  • Pain
  • Opioid
  • Endurance
  • Cognitive
  • Athletes
  • Exercise

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