Transdermal delivery of hydrophobic and hydrophilic local anesthetics from o/w and w/o Brij 97-based microemulsions

Varaporn Buraphacheep Junyaprasert; Prapaporn Boonme; Sarunyoo Songkro; Karen Krauel; Thomas Rades

Transdermal delivery of hydrophobic and hydrophilic local anesthetics from o/w and w/o Brij 97-based microemulsions

Varaporn Buraphacheep Junyaprasert, Prapaporn Boonme, Sarunyoo Songkro, Karen Krauel, Thomas Rades

Research output: Contribution to journal › Journal article › Research › peer-review

71 Citations (Scopus)

Abstract

To characterize the physicochemical properties of drug-loaded oil-in-water (o/w) and water-in-oil (w/o) Brij 97-based microemulsions in comparison to their blank counterparts and to investigate the influence of microemulsion type on in vitro skin permeation of model hydrophobic drugs and their hydrophilic salts.

Original language	English
Journal	Journal of Pharmacy and Pharmaceutical Sciences
Volume	10
Issue number	3
Pages (from-to)	288-98
Number of pages	11
ISSN	1482-1826
Publication status	Published - 2007

Keywords

1-Butanol
Administration, Cutaneous
Anesthetics, Local
Calorimetry, Differential Scanning
Dibucaine
Electric Conductivity
Emulsions
Epidermis
Humans
Hydrogen-Ion Concentration
Hydrophobic and Hydrophilic Interactions
Lidocaine
Molecular Weight
Palmitates
Permeability
Plant Oils
Polyethylene Glycols
Skin Absorption
Tetracaine
Viscosity
Water

Cite this

Transdermal delivery of hydrophobic and hydrophilic local anesthetics from o/w and w/o Brij 97-based microemulsions. / Junyaprasert, Varaporn Buraphacheep; Boonme, Prapaporn; Songkro, Sarunyoo et al.
In: Journal of Pharmacy and Pharmaceutical Sciences, Vol. 10, No. 3, 2007, p. 288-98.

Research output: Contribution to journal › Journal article › Research › peer-review

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abstract = "To characterize the physicochemical properties of drug-loaded oil-in-water (o/w) and water-in-oil (w/o) Brij 97-based microemulsions in comparison to their blank counterparts and to investigate the influence of microemulsion type on in vitro skin permeation of model hydrophobic drugs and their hydrophilic salts.",

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T1 - Transdermal delivery of hydrophobic and hydrophilic local anesthetics from o/w and w/o Brij 97-based microemulsions

AU - Junyaprasert, Varaporn Buraphacheep

AU - Boonme, Prapaporn

AU - Songkro, Sarunyoo

AU - Krauel, Karen

AU - Rades, Thomas

PY - 2007

Y1 - 2007

N2 - To characterize the physicochemical properties of drug-loaded oil-in-water (o/w) and water-in-oil (w/o) Brij 97-based microemulsions in comparison to their blank counterparts and to investigate the influence of microemulsion type on in vitro skin permeation of model hydrophobic drugs and their hydrophilic salts.

AB - To characterize the physicochemical properties of drug-loaded oil-in-water (o/w) and water-in-oil (w/o) Brij 97-based microemulsions in comparison to their blank counterparts and to investigate the influence of microemulsion type on in vitro skin permeation of model hydrophobic drugs and their hydrophilic salts.

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KW - Administration, Cutaneous

KW - Anesthetics, Local

KW - Calorimetry, Differential Scanning

KW - Dibucaine

KW - Electric Conductivity

KW - Emulsions

KW - Epidermis

KW - Humans

KW - Hydrogen-Ion Concentration

KW - Hydrophobic and Hydrophilic Interactions

KW - Lidocaine

KW - Molecular Weight

KW - Palmitates

KW - Permeability

KW - Plant Oils

KW - Polyethylene Glycols

KW - Skin Absorption

KW - Tetracaine

KW - Viscosity

KW - Water

M3 - Journal article

C2 - 17727792

SN - 1482-1826

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SP - 288

EP - 298

JO - Journal of Pharmacy and Pharmaceutical Sciences

JF - Journal of Pharmacy and Pharmaceutical Sciences

IS - 3

ER -