Transport characteristics of L-carnosine and the anticancer derivative 4-toluenesulfonylureido-carnosine in a human epithelial cell line

Carsten Uhd Nielsen, Claudiu T Supuran, Andrea Scozzafava, Sven Frokjaer, Bente Steffansen, Birger Brodin

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    Abstract

    The aim of the present study was to evaluate whether the transepithelial transport of the anticancer compound 4-toluenesulfonylureido-carnosine (Ts-carnosine) and the dipeptide moiety L-carnosine was due to a hPepT1 carrier-mediated flux.
    Original languageEnglish
    JournalPharmaceutical Research
    Volume19
    Issue number9
    Pages (from-to)1337-44
    Number of pages8
    ISSN0724-8741
    Publication statusPublished - 2002

    Keywords

    • Antineoplastic Agents
    • Biological Transport
    • Caco-2 Cells
    • Carnosine
    • Epithelial Cells
    • Humans
    • Intestinal Mucosa
    • Tosyl Compounds

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