Treatment of traumatized refugees with Sertraline versus Venlafaxine in combination with psychotherapy - study protocol for a randomized clinical trial

Charlotte Sonne, Jessica Carlsson, Ask Elklit, Erik Lykke Mortensen, Morten Ekstrøm

Research output: Contribution to journalJournal articleResearchpeer-review

11 Citations (Scopus)

Abstract

Sufficient evidence is lacking to draw final conclusions on the efficiency of medical and psychological treatments of traumatized refugees with PTSD. The pharmacological treatments of choice today for post-traumatic stress disorder are antidepressants from the subgroup selective serotonin reuptake inhibitors, especially Sertraline. The evidence for the use of selective serotonin reuptake inhibitors in the treatment of complex post-traumatic stress disorder in traumatized refugees is very limited. Venlafaxine is a dual-action antidepressant that works on several pathways in the brain. It influences areas in the brain which are responsible for the enhanced anxiety and hyper-arousal experienced by traumatized refugees and which some studies have found to be enlarged among patients suffering from post-traumatic stress disorder.
Original languageEnglish
Article number137
JournalTrials
Volume14
ISSN1745-6215
DOIs
Publication statusPublished - 2013

Cite this