Abstract
BACKGROUND: Patients with moderate-to-severe psoriasis are candidates for systemic treatment, but it is unknown how many receive such therapy at a national level in Denmark.
OBJECTIVES: We aimed to determine the prevalence of conventional systemic therapy use in patients with moderate-to-severe psoriasis, and further, to investigate the time to discontinuation of conventional systemic therapy and initiation of biological therapy among bio-naïve patients.
METHOD: This registry-based study identified a cohort of patients with psoriasis in Denmark. We estimated the prevalence of moderate-to-severe psoriasis at a national level using registry data. Inverse probability weighting was used to mitigate the potential selection bias in the prevalence-estimate of moderate-to-severe psoriasis.
RESULTS: Of patients with psoriasis in Denmark, 10.9% were estimated to have moderate-to-severe psoriasis of whom 62.3% received either conventional systemic or biological therapy meaning 37.7% who were considered candidates for systemic therapy did not receive any systemic treatment. The study demonstrated that time on conventional systemic therapy for patients with moderate-to-severe psoriasis was shorter today than previous (median time of 3.0 years in 1985-1994 vs. 0.6 years in 2014-2018), more patients initiated biologic therapy as second-line therapy with 69.5% in 2010-2013 and 71.2% in 2014-2018 and the median time from initiation of systemic therapy to initiation of biological therapy decreased from 13.3 years in 2010-2013 to 1.9 years in 2014-2018.
CONCLUSION: This study found that nearly 37.7% of the patients with moderate-to-severe psoriasis do not receive systemic treatment even though they would qualify for this. Further, for patients treated with conventional systemics, the drug survival decreased during the observation period.
Original language | English |
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Journal | Clinical and Experimental Dermatology |
Volume | 49 |
Issue number | 1 |
Pages (from-to) | 35–41 |
Number of pages | 7 |
ISSN | 0307-6938 |
DOIs | |
Publication status | Published - 2024 |