Using in vitro lipolysis and SPECT/CT in vivo imaging to understand oral absorption of fenofibrate from lipid-based drug delivery systems

Thuy Tran; Peter Bonlokke; Cristina Rodriguez-Rodriguez; Zeynab Nosrati; Pedro Luis Esquinas; Nrupa Borkar; Jakob Plum; Sophie Strindberg; Stoyan Karagiozov; Thomas Rades; Anette Mullertz; Katayoun Saatchi; Urs O. Hafeli

doi:10.1016/j.jconrel.2019.11.024

Using in vitro lipolysis and SPECT/CT in vivo imaging to understand oral absorption of fenofibrate from lipid-based drug delivery systems

Thuy Tran, Peter Bonlokke, Cristina Rodriguez-Rodriguez, Zeynab Nosrati, Pedro Luis Esquinas, Nrupa Borkar, Jakob Plum, Sophie Strindberg, Stoyan Karagiozov, Thomas Rades, Anette Mullertz, Katayoun Saatchi, Urs O. Hafeli

Research output: Contribution to journal › Journal article › Research › peer-review

10 Citations (Scopus)

Original language	English
Journal	Journal of Controlled Release
Volume	317
Pages (from-to)	375-384
ISSN	0168-3659
DOIs	https://doi.org/10.1016/j.jconrel.2019.11.024
Publication status	Published - 2020

Keywords

Lipid-based drug delivery systems
Monoacyl phosphatidylcholine
Surfactant
SPECT/CT
in vitro lipolysis
Pharmacokinetics
Biodistribution
Fenofibrate
Dual radioisotope imaging

Access to Document

10.1016/j.jconrel.2019.11.024

Cite this

Tran, T., Bonlokke, P., Rodriguez-Rodriguez, C., Nosrati, Z., Esquinas, P. L., Borkar, N., Plum, J., Strindberg, S., Karagiozov, S., Rades, T., Mullertz, A., Saatchi, K., & Hafeli, U. O. (2020). Using in vitro lipolysis and SPECT/CT in vivo imaging to understand oral absorption of fenofibrate from lipid-based drug delivery systems. Journal of Controlled Release, 317, 375-384. https://doi.org/10.1016/j.jconrel.2019.11.024

Using in vitro lipolysis and SPECT/CT in vivo imaging to understand oral absorption of fenofibrate from lipid-based drug delivery systems. / Tran, Thuy; Bonlokke, Peter; Rodriguez-Rodriguez, Cristina; Nosrati, Zeynab; Esquinas, Pedro Luis; Borkar, Nrupa; Plum, Jakob; Strindberg, Sophie; Karagiozov, Stoyan; Rades, Thomas ; Mullertz, Anette; Saatchi, Katayoun; Hafeli, Urs O.

In: Journal of Controlled Release, Vol. 317, 2020, p. 375-384.

Research output: Contribution to journal › Journal article › Research › peer-review

Tran, T, Bonlokke, P, Rodriguez-Rodriguez, C, Nosrati, Z, Esquinas, PL, Borkar, N, Plum, J, Strindberg, S, Karagiozov, S, Rades, T , Mullertz, A, Saatchi, K & Hafeli, UO 2020, 'Using in vitro lipolysis and SPECT/CT in vivo imaging to understand oral absorption of fenofibrate from lipid-based drug delivery systems', Journal of Controlled Release, vol. 317, pp. 375-384. https://doi.org/10.1016/j.jconrel.2019.11.024

Tran, Thuy ; Bonlokke, Peter ; Rodriguez-Rodriguez, Cristina ; Nosrati, Zeynab ; Esquinas, Pedro Luis ; Borkar, Nrupa ; Plum, Jakob ; Strindberg, Sophie ; Karagiozov, Stoyan ; Rades, Thomas ; Mullertz, Anette ; Saatchi, Katayoun ; Hafeli, Urs O. / Using in vitro lipolysis and SPECT/CT in vivo imaging to understand oral absorption of fenofibrate from lipid-based drug delivery systems. In: Journal of Controlled Release. 2020 ; Vol. 317. pp. 375-384.

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keywords = "Lipid-based drug delivery systems, Monoacyl phosphatidylcholine, Surfactant, SPECT/CT, in vitro lipolysis, Pharmacokinetics, Biodistribution, Fenofibrate, Dual radioisotope imaging",

author = "Thuy Tran and Peter Bonlokke and Cristina Rodriguez-Rodriguez and Zeynab Nosrati and Esquinas, {Pedro Luis} and Nrupa Borkar and Jakob Plum and Sophie Strindberg and Stoyan Karagiozov and Thomas Rades and Anette Mullertz and Katayoun Saatchi and Hafeli, {Urs O.}",

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AU - Bonlokke, Peter

AU - Rodriguez-Rodriguez, Cristina

AU - Nosrati, Zeynab

AU - Esquinas, Pedro Luis

AU - Borkar, Nrupa

AU - Plum, Jakob

AU - Strindberg, Sophie

AU - Karagiozov, Stoyan

AU - Rades, Thomas

AU - Mullertz, Anette

AU - Saatchi, Katayoun

AU - Hafeli, Urs O.

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KW - Lipid-based drug delivery systems

KW - Monoacyl phosphatidylcholine

KW - Surfactant

KW - SPECT/CT

KW - in vitro lipolysis

KW - Pharmacokinetics

KW - Biodistribution

KW - Fenofibrate

KW - Dual radioisotope imaging

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DO - 10.1016/j.jconrel.2019.11.024

M3 - Journal article

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VL - 317

SP - 375

EP - 384

JO - Journal of Controlled Release

JF - Journal of Controlled Release

SN - 0168-3659

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