Using terahertz pulsed spectroscopy to study crystallinity of pharmaceutical materials

Clare J. Strachan, Thomas Rades, David A. Newnham, Keith C. Gordon, Michael Pepper, Philip F. Taday*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

240 Citations (Scopus)

Abstract

The application of terahertz pulsed spectroscopy to polymorphic, liquid crystalline and amorphous forms of pharmaceutical compounds has been investigated. The different polymorphic forms of carbamazepine and enalapril maleate exhibit distinct terahertz absorbance spectra. In contrast to crystalline indomethacin and fenoprofen calcium, amorphous indomethacin and liquid crystalline fenoprofen calcium show no absorption modes, which is likely to be due to a lack of order. These findings suggest that the modes observed are due to crystalline phonon and possibly hydrogen-bonding vibrations. The large spectral differences between different forms of the compounds studied is evidence that terahertz pulsed spectroscopy is well-suited to distinguishing crystallinity differences in pharmaceutical compounds.

Original languageEnglish
JournalChemical Physics Letters
Volume390
Issue number1-3
Pages (from-to)20-24
Number of pages5
ISSN0009-2614
DOIs
Publication statusPublished - 21 May 2004

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