UV-Guided isolation of alantrypinone, a novel Penicillium alkaloid

T O Larsen; Karla Andrea Frydenvang; Jens Christian Frisvad; C Christophersen

doi:10.1021/np980056v

UV-Guided isolation of alantrypinone, a novel Penicillium alkaloid

T O Larsen, Karla Andrea Frydenvang, Jens Christian Frisvad, C Christophersen

Department of Chemistry

Research output: Contribution to journal › Journal article › Research › peer-review

93 Citations (Scopus)

Abstract

Fumiquinazoline F (1) and alantrypinone (2) have been isolated as the two major metabolites of Penicillium thymicola. The structure of 2, which contains a new ring structure, was elucidated by analysis of spectroscopic data including 2D NMR. The absolute configuration of 2 was established by a single-crystal X-ray diffraction study.

Original language	English
Journal	Journal of Natural Products
Volume	61
Issue number	9
Pages (from-to)	1154-7
Number of pages	4
ISSN	0163-3864
DOIs	https://doi.org/10.1021/np980056v
Publication status	Published - 1998

Keywords

Alkaloids
Carbohydrate Sequence
Crystallography, X-Ray
Indoles
Magnetic Resonance Spectroscopy
Molecular Conformation
Molecular Sequence Data
Penicillium
Quinazolines
Spectrophotometry, Ultraviolet

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10.1021/np980056v

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title = "UV-Guided isolation of alantrypinone, a novel Penicillium alkaloid",

abstract = "Fumiquinazoline F (1) and alantrypinone (2) have been isolated as the two major metabolites of Penicillium thymicola. The structure of 2, which contains a new ring structure, was elucidated by analysis of spectroscopic data including 2D NMR. The absolute configuration of 2 was established by a single-crystal X-ray diffraction study.",

keywords = "Alkaloids, Carbohydrate Sequence, Crystallography, X-Ray, Indoles, Magnetic Resonance Spectroscopy, Molecular Conformation, Molecular Sequence Data, Penicillium, Quinazolines, Spectrophotometry, Ultraviolet",

author = "Larsen, {T O} and Frydenvang, {Karla Andrea} and Frisvad, {Jens Christian} and C Christophersen",

year = "1998",

doi = "10.1021/np980056v",

language = "English",

volume = "61",

pages = "1154--7",

journal = "Journal of Natural Products",

issn = "0163-3864",

publisher = "American Chemical Society",

number = "9",

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T1 - UV-Guided isolation of alantrypinone, a novel Penicillium alkaloid

AU - Larsen, T O

AU - Frydenvang, Karla Andrea

AU - Frisvad, Jens Christian

AU - Christophersen, C

PY - 1998

Y1 - 1998

N2 - Fumiquinazoline F (1) and alantrypinone (2) have been isolated as the two major metabolites of Penicillium thymicola. The structure of 2, which contains a new ring structure, was elucidated by analysis of spectroscopic data including 2D NMR. The absolute configuration of 2 was established by a single-crystal X-ray diffraction study.

AB - Fumiquinazoline F (1) and alantrypinone (2) have been isolated as the two major metabolites of Penicillium thymicola. The structure of 2, which contains a new ring structure, was elucidated by analysis of spectroscopic data including 2D NMR. The absolute configuration of 2 was established by a single-crystal X-ray diffraction study.

KW - Alkaloids

KW - Carbohydrate Sequence

KW - Crystallography, X-Ray

KW - Indoles

KW - Magnetic Resonance Spectroscopy

KW - Molecular Conformation

KW - Molecular Sequence Data

KW - Penicillium

KW - Quinazolines

KW - Spectrophotometry, Ultraviolet

U2 - 10.1021/np980056v

DO - 10.1021/np980056v

M3 - Journal article

C2 - 9748389

SN - 0163-3864

VL - 61

SP - 1154

EP - 1157

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 9

ER -