Variants in the 5' region of the neuropeptide Y receptor Y2 gene (NPY2R) are associated with obesity in 5,971 white subjects

Signe Sørensen Torekov, L H Larsen, G Andersen, A Albrechtsen, C Glümer, K Borch-Johnsen, T Jørgensen, T Hansen, O Pedersen

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Abstract

The gene encoding neuropeptide Y receptor Y2 (NPY2R) is widely expressed in the central nervous system, with particularly high abundance in the hypothalamus, which is known to be important for appetite regulation. We tested whether variations in NPY2R are associated with obesity.
Original languageEnglish
JournalDiabetologia
Volume49
Issue number11
Pages (from-to)2653-8
Number of pages6
ISSN0012-186X
DOIs
Publication statusPublished - 2006

Keywords

  • 5' Untranslated Regions
  • Aged
  • Aged, 80 and over
  • Blood Glucose
  • Body Mass Index
  • Body Size
  • DNA
  • Denmark
  • Diabetes Mellitus, Type 2
  • European Continental Ancestry Group
  • Genetic Variation
  • Humans
  • Linkage Disequilibrium
  • Middle Aged
  • Obesity
  • Polymorphism, Single Nucleotide
  • Receptors, Neuropeptide Y

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