Vitamin d status, filaggrin genotype, and cardiovascular risk factors: a mendelian randomization approach

Tea Skaaby; Lise Lotte Nystrup Husemoen; Torben Martinussen; Jacob P Thyssen; Michael Melgaard; Betina Heinsbæk Thuesen; Charlotta Pisinger; Torben Jørgensen; Jeanne D Johansen; Torkil Menné; Berit Carlsen; Pal B Szecsi; Steen Stender; Runa Vavia Fenger; Mogens Fenger; Allan Linneberg

doi:10.1371/journal.pone.0057647

Vitamin d status, filaggrin genotype, and cardiovascular risk factors: a mendelian randomization approach

Tea Skaaby, Lise Lotte Nystrup Husemoen, Torben Martinussen, Jacob P Thyssen, Michael Melgaard, Betina Heinsbæk Thuesen, Charlotta Pisinger, Torben Jørgensen, Jeanne D Johansen, Torkil Menné, Berit Carlsen, Pal B Szecsi, Steen Stender, Runa Vavia Fenger, Mogens Fenger, Allan Linneberg

Research output: Contribution to journal › Journal article › Research › peer-review

56 Citations (Scopus)

Abstract

Vitamin D deficiency is associated with increased cardiovascular disease risk in observational studies. Whether these associations are causal is not clear. Loss-of-function mutations in the filaggrin gene result in up to 10% higher serum vitamin D concentrations, supposedly due to a decreased UV-protection of the keratinocytes. We used a Mendelian randomization approach to estimate the causal effect of vitamin D status on serum lipids, blood pressure, body mass index, waist circumference, and the metabolic syndrome.

Original language	English
Journal	P L o S One
Volume	8
Issue number	2
Pages (from-to)	e57647
ISSN	1932-6203
DOIs	https://doi.org/10.1371/journal.pone.0057647
Publication status	Published - 2013

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10.1371/journal.pone.0057647

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Skaaby, T., Husemoen, L. L. N., Martinussen, T., Thyssen, J. P., Melgaard, M., Thuesen, B. H., Pisinger, C., Jørgensen, T., Johansen, J. D., Menné, T., Carlsen, B., Szecsi, P. B., Stender, S., Fenger, R. V., Fenger, M., & Linneberg, A. (2013). Vitamin d status, filaggrin genotype, and cardiovascular risk factors: a mendelian randomization approach. P L o S One, 8(2), e57647. https://doi.org/10.1371/journal.pone.0057647

Vitamin d status, filaggrin genotype, and cardiovascular risk factors : a mendelian randomization approach. / Skaaby, Tea; Husemoen, Lise Lotte Nystrup; Martinussen, Torben; Thyssen, Jacob P; Melgaard, Michael; Thuesen, Betina Heinsbæk; Pisinger, Charlotta; Jørgensen, Torben; Johansen, Jeanne D; Menné, Torkil; Carlsen, Berit; Szecsi, Pal B; Stender, Steen; Fenger, Runa Vavia; Fenger, Mogens; Linneberg, Allan.

In: P L o S One, Vol. 8, No. 2, 2013, p. e57647.

Research output: Contribution to journal › Journal article › Research › peer-review

Skaaby, T, Husemoen, LLN, Martinussen, T, Thyssen, JP, Melgaard, M, Thuesen, BH, Pisinger, C, Jørgensen, T, Johansen, JD, Menné, T, Carlsen, B, Szecsi, PB, Stender, S, Fenger, RV, Fenger, M & Linneberg, A 2013, 'Vitamin d status, filaggrin genotype, and cardiovascular risk factors: a mendelian randomization approach', P L o S One, vol. 8, no. 2, pp. e57647. https://doi.org/10.1371/journal.pone.0057647

Skaaby, Tea ; Husemoen, Lise Lotte Nystrup ; Martinussen, Torben ; Thyssen, Jacob P ; Melgaard, Michael ; Thuesen, Betina Heinsbæk ; Pisinger, Charlotta ; Jørgensen, Torben ; Johansen, Jeanne D ; Menné, Torkil ; Carlsen, Berit ; Szecsi, Pal B ; Stender, Steen ; Fenger, Runa Vavia ; Fenger, Mogens ; Linneberg, Allan. / Vitamin d status, filaggrin genotype, and cardiovascular risk factors : a mendelian randomization approach. In: P L o S One. 2013 ; Vol. 8, No. 2. pp. e57647.

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AB - Vitamin D deficiency is associated with increased cardiovascular disease risk in observational studies. Whether these associations are causal is not clear. Loss-of-function mutations in the filaggrin gene result in up to 10% higher serum vitamin D concentrations, supposedly due to a decreased UV-protection of the keratinocytes. We used a Mendelian randomization approach to estimate the causal effect of vitamin D status on serum lipids, blood pressure, body mass index, waist circumference, and the metabolic syndrome.

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