Volume sensing in the transient receptor potential vanilloid 4 ion channel is cell type-specific and mediated by an N-terminal volume-sensing domain

Trine L. Toft-Bertelsen, Oleg Yarishkin, Sarah Redmon, Tam T. T. Phuong, David Krizaj, Nanna MacAulay

Research output: Contribution to journalJournal articleResearchpeer-review

28 Citations (Scopus)
39 Downloads (Pure)
Original languageEnglish
JournalJournal of Biological Chemistry
Volume294
Issue number48
Pages (from-to)18421-18434
Number of pages14
ISSN0021-9258
DOIs
Publication statusPublished - 2019

Keywords

  • transient receptor potential channels (TRP channels)
  • aquaporin 4 (AQP4)
  • polyunsaturated fatty acid (PUFA)
  • lipid
  • retina
  • osmo-sensing
  • osmo-sensor
  • transient receptor potential vanilloid 4 (TRPV4)
  • volume sensing
  • volume sensor
  • cell swelling
  • phospholipase A2 (PLA2)
  • 5?
  • 6?-epoxy-8Z
  • 11Z
  • 14Z-eicosatrienoic acid (5?
  • 6?-EET)
  • glaucoma
  • Xenopus oocytes
  • M?ller cells
  • retinal ganglion cells

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