TY - JOUR
T1 - Weight Loss Induces Changes in Vitamin D Status in Women with Obesity but not in Men
T2 - a Randomized Clinical Trial
AU - Holt, Rune
AU - Holt, Joachim
AU - Jorsal, Mads Joon
AU - Sandsdal, Rasmus M
AU - Jensen, Simon B K
AU - Byberg, Sarah
AU - Juhl, Christian Rimer
AU - Lundgren, Julie Rehné
AU - Janus, Charlotte
AU - Stallknecht, Bente Merete
AU - Holst, Jens Juul
AU - Juul, Anders
AU - Madsbad, Sten
AU - Jensen, Martin Blomberg
AU - Torekov, Signe Sørensen
N1 - © The Author(s) 2024. Published by Oxford University Press on behalf of the Endocrine Society.
PY - 2024
Y1 - 2024
N2 - CONTEXT: Obesity is associated with low vitamin D and recent studies have suggested a difference in vitamin D metabolism between females and males.OBJECTIVE: The aim of this study was to investigate the effects of weight loss on vitamin D status in individuals with obesity, and secondarily, whether vitamin D metabolism differs between women and men.METHODS: Secondary analysis from a randomized placebo-controlled trial, designed to investigate the efficacy of 52 weeks of treatment with either liraglutide, exercise or combined, compared with placebo on weight loss maintenance after an 8-week low-calorie diet-induced weight loss in 195 individuals with obesity (BMI 32-43 kg/m2).RESULTS: The low-calorie diet-induced weight loss resulted in an increase in serum 25(OH)D in both women and men (12 nmol/L (95%CI 9-15) and 13 nmol/L (95%CI 8-17); p < 0.001 for both). Women who experienced a further weight loss during the 52 weeks of intervention had an increase in serum 25(OH)D compared with women regaining weight (14 nmol/L (95%CI 6-22); p = 0.001). Interestingly, women experiencing further weight loss at week 52 had a lower serum 25(OH)D at baseline compared with women regaining weight (54 nmol/L (SD 19) vs. 70 nmol/L (SD 25); p < 0.001).CONCLUSION: Weight loss induced by a low-calorie diet resulted in an increase in serum 25(OH)D in both women and men. Only in women, further weight loss had an additional beneficial impact on vitamin D. Additionally, initial low serum 25(OH)D was associated with successful weight loss maintenance in women, but not men.
AB - CONTEXT: Obesity is associated with low vitamin D and recent studies have suggested a difference in vitamin D metabolism between females and males.OBJECTIVE: The aim of this study was to investigate the effects of weight loss on vitamin D status in individuals with obesity, and secondarily, whether vitamin D metabolism differs between women and men.METHODS: Secondary analysis from a randomized placebo-controlled trial, designed to investigate the efficacy of 52 weeks of treatment with either liraglutide, exercise or combined, compared with placebo on weight loss maintenance after an 8-week low-calorie diet-induced weight loss in 195 individuals with obesity (BMI 32-43 kg/m2).RESULTS: The low-calorie diet-induced weight loss resulted in an increase in serum 25(OH)D in both women and men (12 nmol/L (95%CI 9-15) and 13 nmol/L (95%CI 8-17); p < 0.001 for both). Women who experienced a further weight loss during the 52 weeks of intervention had an increase in serum 25(OH)D compared with women regaining weight (14 nmol/L (95%CI 6-22); p = 0.001). Interestingly, women experiencing further weight loss at week 52 had a lower serum 25(OH)D at baseline compared with women regaining weight (54 nmol/L (SD 19) vs. 70 nmol/L (SD 25); p < 0.001).CONCLUSION: Weight loss induced by a low-calorie diet resulted in an increase in serum 25(OH)D in both women and men. Only in women, further weight loss had an additional beneficial impact on vitamin D. Additionally, initial low serum 25(OH)D was associated with successful weight loss maintenance in women, but not men.
U2 - 10.1210/clinem/dgae775
DO - 10.1210/clinem/dgae775
M3 - Journal article
C2 - 39530599
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
SN - 0021-972X
ER -