Abstract
OBJECTIVE: The aim of this study was to investigate glucose tolerance, glucagon response, and beta cell function during a 1-year maintenance period with either exercise, the glucagon-like peptide-1 receptor agonist liraglutide, or the combination after diet-induced weight loss.
METHODS: In this randomized placebo-controlled trial, adults with obesity (BMI: 32-43 kg/m 2 ) without diabetes underwent an 8-week low-calorie diet (800 kcal/d) and were randomized to 52 weeks of aerobic exercise, liraglutide 3.0 mg/d, exercise and liraglutide combined, or placebo. Change in glucose and glucagon response to a 3-hour mixed meal test and disposition index, as a measure of beta cell function, were measured.
RESULTS: A total of 195 participants were randomized. After 1 year of treatment, the combination group had decreased postprandial glucose response by -9% (95% CI: -14% to -3%; p = 0.002), improved beta cell function by 49% (95% CI: 16% to 93%; p = 0.002), and decreased glucagon response by -18% (95% CI: -34% to -3%; p = 0.024) compared with placebo. Compared with placebo, liraglutide alone improved postprandial glucose response by -7% (95% CI: -12% to -1%; p = 0.018), but not beta cell function or glucagon. Exercise alone had similar postprandial glucose response, beta cell function, and glucagon response as placebo.
CONCLUSIONS: Only the combination of exercise and liraglutide improved glucose tolerance, beta cell function, and glucagon responses after weight loss.
Original language | English |
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Journal | Obesity |
Volume | 31 |
Issue number | 4 |
Pages (from-to) | 977-989 |
Number of pages | 13 |
ISSN | 1930-7381 |
DOIs | |
Publication status | Published - 2023 |
Bibliographical note
© 2023 The Authors. Obesity published by Wiley Periodicals LLC on behalf of The Obesity Society.Keywords
- Adult
- Humans
- Liraglutide/pharmacology
- Glucagon
- Hypoglycemic Agents/therapeutic use
- Weight Loss
- Exercise
- Glucose
- Double-Blind Method
- Blood Glucose
- Diabetes Mellitus, Type 2/drug therapy