Within-patient horizontal transfer of pOXA-48 from a hypervirulent Klebsiella pneumoniae SL218 to Serratia marcescens following spread of the K. pneumoniae isolate among hospitalised patients, Denmark, 2021

Karen Leth Nielsen; Marc Sørensen; Frederik Boëtius Hertz; Maria Anna Misiakou; Henrik Hasman; Susanne Häussler; Marie Helleberg; Kristian Schønning

doi:10.2807/1560-7917.ES.2023.28.17.2300196

Within-patient horizontal transfer of pOXA-48 from a hypervirulent Klebsiella pneumoniae SL218 to Serratia marcescens following spread of the K. pneumoniae isolate among hospitalised patients, Denmark, 2021

Karen Leth Nielsen, Marc Sørensen, Frederik Boëtius Hertz, Maria Anna Misiakou, Henrik Hasman, Susanne Häussler, Marie Helleberg, Kristian Schønning

Research output: Contribution to journal › Journal article › Research › peer-review

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Abstract

A hypervirulent Klebsiella pneumoniae SL218 (ST23-KL57), phylogenetically distinct from the classical hypervirulent SL23 (ST23-KL1) lineage, was transmitted between hospitalised patients in Denmark in 2021. The isolate carried a hybrid resistance and virulence plasmid containing blaNDM-1 and a plasmid containing blaOXA-48 (pOXA-48); the latter plasmid was horizontally transferred within-patient to Serratia marcescens. The convergence of drug resistance and virulence factors in single plasmids and in different lineages of K. pneumoniae is concerning and requires surveillance.

Original language	English
Journal	Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin
Volume	28
Issue number	17
Number of pages	7
ISSN	1025-496X
DOIs	https://doi.org/10.2807/1560-7917.ES.2023.28.17.2300196
Publication status	Published - 2023

Keywords

antimicrobial resistance
Hospital-acquired infections
hypervirulent K. pneumoniae
OXA-48
within-patient plasmid transfer

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10.2807/1560-7917.ES.2023.28.17.2300196Licence: CC BY

FulltextFinal published version, 402 KBLicence: CC BY

Cite this

Nielsen, K. L., Sørensen, M., Hertz, F. B., Misiakou, M. A., Hasman, H., Häussler, S., Helleberg, M., & Schønning, K. (2023). Within-patient horizontal transfer of pOXA-48 from a hypervirulent Klebsiella pneumoniae SL218 to Serratia marcescens following spread of the K. pneumoniae isolate among hospitalised patients, Denmark, 2021. Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 28(17). https://doi.org/10.2807/1560-7917.ES.2023.28.17.2300196

Within-patient horizontal transfer of pOXA-48 from a hypervirulent Klebsiella pneumoniae SL218 to Serratia marcescens following spread of the K. pneumoniae isolate among hospitalised patients, Denmark, 2021. / Nielsen, Karen Leth; Sørensen, Marc ; Hertz, Frederik Boëtius; Misiakou, Maria Anna; Hasman, Henrik; Häussler, Susanne; Helleberg, Marie ; Schønning, Kristian.

In: Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, Vol. 28, No. 17, 2023.

Research output: Contribution to journal › Journal article › Research › peer-review

Nielsen, KL, Sørensen, M , Hertz, FB, Misiakou, MA, Hasman, H, Häussler, S, Helleberg, M & Schønning, K 2023, 'Within-patient horizontal transfer of pOXA-48 from a hypervirulent Klebsiella pneumoniae SL218 to Serratia marcescens following spread of the K. pneumoniae isolate among hospitalised patients, Denmark, 2021', Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, vol. 28, no. 17. https://doi.org/10.2807/1560-7917.ES.2023.28.17.2300196

Nielsen KL, Sørensen M , Hertz FB, Misiakou MA, Hasman H, Häussler S et al. Within-patient horizontal transfer of pOXA-48 from a hypervirulent Klebsiella pneumoniae SL218 to Serratia marcescens following spread of the K. pneumoniae isolate among hospitalised patients, Denmark, 2021. Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin. 2023;28(17). https://doi.org/10.2807/1560-7917.ES.2023.28.17.2300196

Nielsen, Karen Leth ; Sørensen, Marc ; Hertz, Frederik Boëtius ; Misiakou, Maria Anna ; Hasman, Henrik ; Häussler, Susanne ; Helleberg, Marie ; Schønning, Kristian. / Within-patient horizontal transfer of pOXA-48 from a hypervirulent Klebsiella pneumoniae SL218 to Serratia marcescens following spread of the K. pneumoniae isolate among hospitalised patients, Denmark, 2021. In: Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin. 2023 ; Vol. 28, No. 17.

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