Young men with low birthweight exhibit decreased plasticity of genome-wide muscle DNA methylation by high-fat overfeeding

Stine C Jacobsen; Linn Gillberg; Jette Bork-Jensen; Rasmus Ribel-Madsen; Ester Lara; Vincenzo Calvanese; Charlotte Ling; Agustin F Fernandez; Mario F Fraga; Pernille Poulsen; Charlotte Brøns; Allan Vaag

doi:10.1007/s00125-014-3198-8

Young men with low birthweight exhibit decreased plasticity of genome-wide muscle DNA methylation by high-fat overfeeding

Stine C Jacobsen, Linn Gillberg, Jette Bork-Jensen, Rasmus Ribel-Madsen, Ester Lara, Vincenzo Calvanese, Charlotte Ling, Agustin F Fernandez, Mario F Fraga, Pernille Poulsen, Charlotte Brøns, Allan Vaag

Department of Clinical Medicine

Research output: Contribution to journal › Journal article › Research › peer-review

68 Citations (Scopus)

Abstract

The association between low birthweight (LBW) and risk of developing type 2 diabetes may involve epigenetic mechanisms, with skeletal muscle being a prime target tissue. Differential DNA methylation patterns have been observed in single genes in muscle tissue from type 2 diabetic and LBW individuals, and we recently showed multiple DNA methylation changes during short-term high-fat overfeeding in muscle of healthy people. In a randomised crossover study, we analysed genome-wide DNA promoter methylation in skeletal muscle of 17 young LBW men and 23 matched normal birthweight (NBW) men after a control and a 5 day high-fat overfeeding diet.

Original language	English
Journal	Diabetologia
Volume	57
Issue number	6
Pages (from-to)	1154-1158
Number of pages	5
ISSN	0012-186X
DOIs	https://doi.org/10.1007/s00125-014-3198-8
Publication status	Published - 26 Feb 2014

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10.1007/s00125-014-3198-8

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Jacobsen, S. C., Gillberg, L., Bork-Jensen, J., Ribel-Madsen, R., Lara, E., Calvanese, V., Ling, C., Fernandez, A. F., Fraga, M. F., Poulsen, P., Brøns, C., & Vaag, A. (2014). Young men with low birthweight exhibit decreased plasticity of genome-wide muscle DNA methylation by high-fat overfeeding. Diabetologia, 57(6), 1154-1158. https://doi.org/10.1007/s00125-014-3198-8

Young men with low birthweight exhibit decreased plasticity of genome-wide muscle DNA methylation by high-fat overfeeding. / Jacobsen, Stine C; Gillberg, Linn; Bork-Jensen, Jette; Ribel-Madsen, Rasmus; Lara, Ester; Calvanese, Vincenzo; Ling, Charlotte; Fernandez, Agustin F; Fraga, Mario F; Poulsen, Pernille; Brøns, Charlotte; Vaag, Allan.

In: Diabetologia, Vol. 57, No. 6, 26.02.2014, p. 1154-1158.

Research output: Contribution to journal › Journal article › Research › peer-review

Jacobsen, Stine C ; Gillberg, Linn ; Bork-Jensen, Jette ; Ribel-Madsen, Rasmus ; Lara, Ester ; Calvanese, Vincenzo ; Ling, Charlotte ; Fernandez, Agustin F ; Fraga, Mario F ; Poulsen, Pernille ; Brøns, Charlotte ; Vaag, Allan. / Young men with low birthweight exhibit decreased plasticity of genome-wide muscle DNA methylation by high-fat overfeeding. In: Diabetologia. 2014 ; Vol. 57, No. 6. pp. 1154-1158.

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AU - Lara, Ester

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AU - Fernandez, Agustin F

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