Abstract
Drugs that prolong the QTc interval to clinically relevant magnitudes are likely to be proarrhythmic if they also produce relevant changes in the morphology of repolarization waveforms. Concurrent analyses of QTc and the T-wave Morphology Combination Score (MCS) have already shown how this approach can improve characterization of repolarization effects for a number of drugs. In this study we develop a transformation of MCS values to standardized T-wave Morphology scores (TWM) which have the important advantage of being directly comparable to QTc. We then examined the relative merits of assessing changes in TWM values in addition to QTcF for 37 schizophrenia subjects exposed to Sertindole, a drug which is not considered acceptably safe as a broad treatment of schizophrenia.
Original language | English |
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Title of host publication | Computing in Cardiology 2011, CinC 2011 |
Number of pages | 4 |
Volume | 38 |
Publication date | 1 Dec 2011 |
Pages | 737-740 |
Article number | 6164671 |
ISBN (Print) | 9781457706127 |
Publication status | Published - 1 Dec 2011 |
Event | Computing in Cardiology 2011, CinC 2011 - Hangzhou, China Duration: 18 Sep 2011 → 21 Sep 2011 |
Conference
Conference | Computing in Cardiology 2011, CinC 2011 |
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Country/Territory | China |
City | Hangzhou |
Period | 18/09/2011 → 21/09/2011 |
Sponsor | European Society of Cardiology, Zhejiang University, EMB, IEEE, Drager |